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Prof. Dr.
10/1997 – 11/2002
Studies of Physics
Georg-August-Universität Göttingen
11/2002 – 09/2006
PhD/Postdoctoral studies
Max Planck Institute for Biophysical Chemistry, Göttingen
10/2003 – 04/2004
Research visit
National Institutes of Health, Bethesda, Maryland, USA
10/2006 – 08/2008
Postdoctoral fellow at the Laboratory of Physical Chemistry, EMBO long-term fellowship
ETH Zürich, Switzerland
09/2008 – 03/2014
Research Group Leader
Max Planck Institute for Biophysical Chemistry, Emmy Noether fellowship
04/2014
Department Head
FMP
04/2014
W3 Professur
Humboldt-University of Berlin
2019 – 2021
Executive board member
Einstein Center of Catalysis Berlin
01/2022
Coordinator
Center of Excellence UniSysCat Research Unit E
ICMRBS Founders’ Medal
2016
ERC Starting Grant
"3D structures of bacterial supramolecular assemblies by solid-state NMR"
2013
Otto Hahn Medal of the Max Planck Society
2006
Ernst Award of the German Chemical Society
2006
An anionic two dimensional covalent organic framework from tetratopic borate centres pillared by lithium ions
Nature Communications 2024
online lesenLipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity
Nature Communications 2024
online lesenHomonuclear Simplified Preservation of Equivalent Pathways Spectroscopy
The Journal of Physical Chemistry Letters 2024
online lesenIn Situ Spectroscopic Detection of Large‐Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening**
Angewandte Chemie International Edition 2023
online lesenIn situ‐spektroskopische Detektion der weitreichenden Reorientierung von Transmembranhelices während der Öffnung des Influenza A M2‐Kanals**
Angewandte Chemie 2023
online lesenIn-situ spectroscopic detection of large-scale reorientations of transmembrane α-helices during viroporin channel opening
Accurate Determination of Motional Amplitudes in Biomolecules by Solid-State NMR
ACS Physical Chemistry Au 2023
online lesenThe opening dynamics of the lateral gate regulates the activity of rhomboid proteases
Science Advances 2023
online lesenMajor tail proteins of bacteriophages of the order Caudovirales
Journal of Biological Chemistry 2022
online lesenDirect Detection of Bound Ammonium Ions in the Selectivity Filter of Ion Channels by Solid-State NMR
Journal of the American Chemical Society 2022
online lesenSodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel
Journal of Molecular Biology 2021
online lesenA combination of solid-state NMR and MD simulations reveals the binding mode of a rhomboid protease inhibitor
Chemical Science 2021
online lesenArchitecture of the flexible tail tube of bacteriophage SPP1
Nature Communications 2020
online lesenDynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter
Biochimica et Biophysica Acta (BBA) - Biomembranes 2020
online lesenSpinal Column Architecture of the Flexible SPP1 Bacteriophage Tail Tube
Protein resonance assignment by BSH‐CP‐based 3D solid‐state NMR experiments: A practical guide
Magnetic Resonance in Chemistry 2020
online lesenComparison of the 3D structures of mouse and human α-synuclein fibrils by solid-state NMR and STEM
Journal of Structural Biology 2019
online lesenCharacterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations
Journal of Biomolecular NMR 2019
online lesenThe conduction pathway of potassium channels is water free under physiological conditions
Science Advances 2019
online lesenStructure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR
Journal of the American Chemical Society 2019
online lesenA single NaK channel conformation is not enough for non-selective ion conduction
Nature Communications 2018
online lesenProtein−Protein Interfaces Probed by Methyl Labeling and Proton‐Detected Solid‐State NMR Spectroscopy
ChemPhysChem 2018
online lesenMeasurement of backbone hydrogen-deuterium exchange in the type III secretion system needle protein PrgI by solid-state NMR
Journal of Magnetic Resonance 2017
online lesenEmerin self‐assembly mechanism: role of the LEM domain
The FEBS Journal 2017
online lesenBackbone assignment of perdeuterated proteins by solid-state NMR using proton detection and ultrafast magic-angle spinning
Nature Protocols 2017
online lesenSensory domain contraction in histidine kinase CitA triggers transmembrane signaling in the membrane-bound sensor
Proceedings of the National Academy of Sciences 2017
online lesenA Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions
Journal of the American Chemical Society 2017
online lesenBacteriophage Tail‐Tube Assembly Studied by Proton‐Detected 4D Solid‐State NMR
Angewandte Chemie International Edition 2017
online lesenBacteriophage Tail‐Tube Assembly Studied by Proton‐Detected 4D Solid‐State NMR
Angewandte Chemie 2017
online lesenVoltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1
Biophysical Journal 2016
online lesenHigh resolution observed in 800 MHz DNP spectra of extremely rigid type III secretion needles
Journal of Biomolecular NMR 2016
online lesenUltrafast Magic-Angle Spinning: Benefits for the Acquisition of Ultrawide-Line NMR Spectra of Heavy Spin-1/2 Nuclei
ChemPhysChem 2016
online lesenPerspectives for sensitivity enhancement in proton-detected solid-state NMR of highly deuterated proteins by preserving water magnetization
Journal of Biomolecular NMR 2015
online lesenSolid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2
Journal of Biomolecular NMR 2015
online lesenHybrid Structure of the Type 1 Pilus of UropathogenicEscherichia coli
Angewandte Chemie International Edition 2015
online lesenAtomic-resolution structure of cytoskeletal bactofilin by solid-state NMR
Science Advances 2015
online lesenStructural heterogeneity in microcrystalline ubiquitin studied by solid-state NMR
Protein Science 2015
online lesenSpecific 13C labeling of leucine, valine and isoleucine methyl groups for unambiguous detection of long-range restraints in protein solid-state NMR studies
Journal of Magnetic Resonance 2015
online lesenRecovery of Bulk Proton Magnetization and Sensitivity Enhancement in Ultrafast Magic-Angle Spinning Solid-State NMR
The Journal of Physical Chemistry B 2015
online lesenβ-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR
Proceedings of the National Academy of Sciences 2015
online lesenBSH-CP based 3D solid-state NMR experiments for protein resonance assignment
Journal of Biomolecular NMR 2014
online lesenTowards automatic protein backbone assignment using proton-detected 4D solid-state NMR data
Journal of Biomolecular NMR 2014
online lesenProton-detected MAS NMR experiments based on dipolar transfers for backbone assignment of highly deuterated proteins
Journal of Magnetic Resonance 2014
online lesenNMR-Based Detection of Hydrogen/Deuterium Exchange in Liposome-Embedded Membrane Proteins
PLoS ONE 2014
online lesenHigh-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy
Nature Communications 2014
online lesenRevisiting the Synthesis and Elucidating the Structure of Potassium Cyclopentadienyldicarbonylruthenate, K[CpRu(CO)2]
Organometallics 2014
online lesenSynthetic Access to a Hydrocarbon-Soluble Trifluorinated Ge(II) Compound and its Sn(II) Congener
Journal of the American Chemical Society 2014
online lesenNucleotide Interactions of the Human Voltage-dependent Anion Channel
Journal of Biological Chemistry 2014
online lesenStudies on the MxiH Protein in T3SS Needles Using DNP-Enhanced ssNMR Spectroscopy
ChemPhysChem 2014
online lesenSpontaneous Aggregation of the Insulin-Derived Steric Zipper Peptide VEALYL Results in Different Aggregation Forms with Common Features
Journal of Molecular Biology 2014
online lesenEfficient band-selective homonuclear CO–CA cross-polarization in protonated proteins
Journal of Biomolecular NMR 2013
online lesenCryogenic solid state NMR studies of fibrils of the Alzheimer’s disease amyloid-β peptide: perspectives for DNP
Journal of Biomolecular NMR 2013
online lesenAtomic Structure and Handedness of the Building Block of a Biological Assembly
Journal of the American Chemical Society 2013
online lesenEfficient CO–CA transfer in highly deuterated proteins by band-selective homonuclear cross-polarization
Journal of Magnetic Resonance 2013
online lesenThe Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles
PLoS Pathogens 2013
online lesenA straightforward method for stereospecific assignment of val and leu prochiral methyl groups by solid-state NMR: Scrambling in the [2-13C]Glucose labeling scheme
Journal of Magnetic Resonance 2013
online lesenStructural characterization of supramolecular assemblies by 13C spin dilution and 3D solid-state NMR
Journal of Biomolecular NMR 2013
online lesenβ-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel
Structure 2012
online lesenβ-Sheet Core of Tau Paired Helical Filaments Revealed by Solid-State NMR
Journal of the American Chemical Society 2012
online lesenLewis base mediated dismutation of trichlorosilane
Chemical Communications 2012
online lesenMonomeric Sn(ii) and Ge(ii) hydrides supported by a tridentate pincer-based ligand
Chemical Communications 2012
online lesenStructural Comparison of Mouse and Human α-Synuclein Amyloid Fibrils by Solid-State NMR
Journal of Molecular Biology 2012
online lesenAtomic model of the type III secretion system needle
Nature 2012
online lesenMixed Crystalline Lithium Organics and Interconversion in Solution
Organometallics 2012
online lesenLewis Base Mediated Autoionization of GeCl2 and SnCl2
Journal of the American Chemical Society 2012
online lesenProbing Water Accessibility in HET-s(218–289) Amyloid Fibrils by Solid-State NMR
Journal of Molecular Biology 2011
online lesenZwitterionic Si-C-Si-P and Si-P-Si-P Four-Membered Rings with Two-Coordinate Phosphorus Atoms
Angewandte Chemie International Edition 2011
online lesenPure α-Metallated Benzyllithium from a Single-Crystal-to-Single-Crystal Transition
Angewandte Chemie International Edition 2011
online lesen13C Spin Dilution for Simplified and Complete Solid-State NMR Resonance Assignment of Insoluble Biological Assemblies
Journal of the American Chemical Society 2011
online lesenPreparation of RSn(I)–Sn(I)R with Two Unsymmetrically Coordinated Sn(I) Atoms and Subsequent Gentle Activation of P4
Journal of the American Chemical Society 2011
online lesenProbing Molecular Motion by Double-Quantum (13C,13C) Solid-State NMR Spectroscopy: Application to Ubiquitin
Journal of the American Chemical Society 2010
online lesenFunctional dynamics in the voltage-dependent anion channel
Proceedings of the National Academy of Sciences 2010
online lesenSupramolecular Interactions Probed by13C−13C Solid-State NMR Spectroscopy
Journal of the American Chemical Society 2010
online lesenAtomic-Resolution Three-Dimensional Structure of HET-s(218−289) Amyloid Fibrils by Solid-State NMR Spectroscopy
Journal of the American Chemical Society 2010
online lesenTailored low-power cross-polarization under fast magic-angle spinning
Journal of Magnetic Resonance 2010
online lesenProtein refolding is required for assembly of the type three secretion needle
Nature Structural & Molecular Biology 2010
online lesenHighly preorganized pyrazolate-bridged palladium(ii) and nickel(ii) complexes in bimetallic norbornene polymerization
Dalton Transactions 2010
online lesenThe Native Conformation of the Human VDAC1 N Terminus
Angewandte Chemie International Edition 2010
online lesenStructural Properties of Pore-Forming Oligomers of α-Synuclein
Journal of the American Chemical Society 2009
online lesenLow-Power Solid-State NMR Experiments for Resonance Assignment under Fast Magic-Angle Spinning
ChemPhysChem 2009
online lesenA Combined Solid-State NMR and MD Characterization of the Stability and Dynamics of the HET-s(218-289) Prion in its Amyloid Conformation
ChemBioChem 2009
online lesenLow-power cross polarization in fast magic-angle spinning NMR experiments
Chemical Physics Letters 2009
online lesenInfectious and Noninfectious Amyloids of the HET‐s(218–289) Prion Have Different NMR Spectra
Angewandte Chemie International Edition 2008
online lesenHigh-Resolution 3D Structure Determination of Kaliotoxin by Solid-State NMR Spectroscopy
PLoS ONE 2008
online lesenAmyloid Fibrils of the HET-s(218-289) Prion Form a Solenoid with a Triangular Hydrophobic Core
Science 2008
online lesenSolid-State NMR Spectroscopy Applied to a Chimeric Potassium Channel in Lipid Bilayers†
Journal of the American Chemical Society 2008
online lesenThe Molecular Mechanism of Toxin-Induced Conformational Changes in a Potassium Channel: Relation to C-Type Inactivation
Structure 2008
online lesenA structural link between inactivation and block of a K+ channel
Nature Structural & Molecular Biology 2008
online lesenProtein solid-state NMR resonance assignments from (13C,13C) correlation spectroscopy
Physical Chemistry Chemical Physics 2004
online lesenProbing Molecular Interfaces Using 2D Magic-Angle-Spinning NMR on Protein Mixtures with Different Uniform Labeling
Journal of the American Chemical Society 2004
online lesenSolid state NMR sequential resonance assignments and conformational analysis of the 2 × 10.4 kDa dimeric form of the Bacillus subtilis protein Crh
Journal of Biomolecular NMR 2003
online lesenAnalysis of Proton−Proton Transfer Dynamics in Rotating Solids and Their Use for 3D Structure Determination
Journal of the American Chemical Society 2003
online lesenDas Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) gehört zum Forschungsverbund Berlin e.V. (FVB), einem Zusammenschluss von sieben natur-, lebens- und umweltwissenschaftlichen Instituten in Berlin. Die Einrichtungen sind Mitglieder der Leibniz-Gemeinschaft.
Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Deutschland