Martin Neuenschwander

DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones

• Nicholas S. O'Brien; Jing Xue; Claudia Bahnik; Martin Neuenschwander; Michael Kraub; Phillip J. Robinson; Volker Haucke; Adam McCluskey

European Journal of Medicinal Chemistry 2026

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

• Kate Prichard; Mark J. Robertson; Ngoc Chau; Jing Xue; Martin Neuenschwander; Uwe Fink; Andre Horatscheck; Marc Nazare; Phillip J. Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2025

Front Cover: Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety (ChemMedChem 16/2025)

• Kate Prichard; Mark J Robertson; Ngoc Chau; Jing Xue; Martin Neuenschwander; Uwe Fink; Andre Horatscheck; Marc Nazare; Phillip J Robinson; Volker Haucke; Adam McCluskey

ChemMedChem 2025

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

• Mohd, S.; Oder, A.; Specker, E.; Neuenschwander, M.; Von Kries, J.P.; Daumke, O.

bioRxiv 2024

7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

• Brenner, M.; Zink, C.; Witzinger, L.; Keller, A.; Hadamek, K.; Bothe, S.; Neuenschwander, M.; Villmann, C.; von Kries, J.P.; Schindelin, H.; Jeanclos, E.; Gohla, A.

eLife 2024

Pentafluorosulfanyl (SF₅) as a Superior ¹⁹F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

• Prinz, C.; Starke, L.; Ramspoth, T.-F.; Kerkering, J.; Martos Riaño, V.; Paul, J.; Neuenschwander, M.; Oder, A.; Radetzki, S.; Adelhoefer, S.; Ramos Delgado, P.; Aravina, M.; Millward, J.M.; Fillmer, A.; Paul, F.; Siffrin, V.; Von Kries, J.-P.; Niendorf, T.; Nazaré, M.; Waiczies, S.

ACS Sensors 2021

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

• Bonnekoh, H.; Vera, C.; Abad-Perez, A.; Radetzki, S.; Neuenschwander, M.; Specker, E.; Mahnke, N.A.; Frischbutter, S.; Latz, E.; Nazaré, M.; Kries, J.V.; Maurer, M.; Scheffel, J.; Krause, K.

Clinical and Translational Allergy 2021

Author Correction: Loss-of-function uORF mutations in human malignancies (Scientific Reports, (2018), 8, 1, (2395), 10.1038/s41598-018-19201-8)

• Schulz, J.; Mah, N.; Neuenschwander, M.; Kischka, T.; Ratei, R.; Schlag, P.M.; Castaños-Vélez, E.; Fichtner, I.; Tunn, P.-U.; Denkert, C.; Klaas, O.; Berdel, W.E.; von Kries, J.P.; Makalowski, W.; Andrade-Navarro, M.A.; Leutz, A.; Wethmar, K.

Scientific Reports 2021

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

• Mostinski, Y.; Heynen, G.J.J.E.; López-Alberca, M.P.; Paul, J.; Miksche, S.; Radetzki, S.; Schaller, D.; Shanina, E.; Seyffarth, C.; Kolomeets, Y.; Ziebart, N.; De Schryver, J.; Oestreich, S.; Neuenschwander, M.; Roske, Y.; Heinemann, U.; Rademacher, C.; Volkamer, A.; Von Kries, J.P.; Birchmeier, W.; Nazaré, M.

Journal of Medicinal Chemistry 2020

Revealing cytotoxic substructures in molecules using deep learning

• Webel, H.E.; Kimber, T.B.; Radetzki, S.; Neuenschwander, M.; Nazaré, M.; Volkamer, A.

Journal of Computer-Aided Molecular Design 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP

• Dema, A.; Faust, D.; Lazarow, K.; Wippich, M.; Neuenschwander, M.; Zühlke, K.; Geelhaar, A.; Pallien, T.; Hallscheidt, E.; Eichhorst, J.; Wiesner, B.; Černecká, H.; Popp, O.; Mertins, P.; Dittmar, G.; von Kries, J.P.; Klussmann, E.

Cells 2020

Regulation of influenza a virus mRNA splicing by CLK1

• Artarini, A.; Meyer, M.; Shin, Y.J.; Huber, K.; Hilz, N.; Bracher, F.; Eros, D.; Orfi, L.; Keri, G.; Goedert, S.; Neuenschwander, M.; von Kries, J.; Domovich-Eisenberg, Y.; Dekel, N.; Szabadkai, I.; Lebendiker, M.; Horváth, Z.; Danieli, T.; Livnah, O.; Moncorgé, O.; Frise, R.; Barclay, W.; Meyer, T.F.; Karlas, A.

Antiviral Research 2019

A new highly thyrotropin receptor-selective small-molecule antagonist with potential for the treatment of graves' orbitopathy

• Marcinkowski, P.; Hoyer, I.; Specker, E.; Furkert, J.; Rutz, C.; Neuenschwander, M.; Sobottka, S.; Sun, H.; Nazare, M.; Berchner-Pfannschmidt, U.; Von Kries, J.P.; Eckstein, A.; Schülein, R.; Krause, G.

Thyroid 2019

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

• Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J.; Kolanowski, J.L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; von Kries, J.P.; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Leśnikowski, Z.; Krauss, S.; Lehtiö, L.; Bilitewski, U.; Brönstrup, M.; Taskén, K.; Jirgensons, A.; Lickert, H.; Clausen, M.H.; Andersen, J.H.; Vicent, M.J.; Genilloud, O.; Martinez, A.; Nazaré, M.; Fecke, W.; Gribbon, P.

SLAS Discovery 2019

A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis

• Fang, L.; Zhu, Q.; Neuenschwander, M.; Specker, E.; Wulf-Goldenberg, A.; Weis, W.I.; Von Kries, J.P.; Birchmeier, W.

Cancer Research 2016

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

• Wilde, F.; Specker, E.; Neuenschwander, M.; Nazaré, M.; Bodtke, A.; Link, A.

Molecular Diversity 2014

Functional mapping of protein-protein interactions in an enzyme complex by directed evolution

• Roderer, K.; Neuenschwander, M.; Codoni, G.; Sasso, S.; Gamper, M.; Kast, P.

PloS one 2014

Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A

• Schröder, D.; Rehbach, C.; Seyffarth, C.; Neuenschwander, M.; Kries, J.V.; Windhorst, S.

Biochemical and Biophysical Research Communications 2013

Small-molecule screening identifies modulators of aquaporin-2 trafficking

• Bogum, J.; Faust, D.; Zuḧlke, K.; Eichhorst, J.; Moutty, M.C.; Furkert, J.; Eldahshan, A.; Neuenschwander, M.; Von Kries, J.P.; Wiesner, B.; Trimpert, C.; Deen, P.M.T.; Valenti, G.; Rosenthal, W.; Klussmann, E.

Journal of the American Society of Nephrology 2013

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

• Nagel, D.; Spranger, S.; Vincendeau, M.; Grau, M.; Raffegerst, S.; Kloo, B.; Hlahla, D.; Neuenschwander, M.; Peter von Kries, J.; Hadian, K.; Dörken, B.; Lenz, P.; Lenz, G.; Schendel, D.; Krappmann, D.

Cancer Cell 2012

Sustainable synthesis and automated deposition: An accessible discovery screening library of fragment-like purines

• Kamper, C.; Korpis, K.; Specker, E.; Anger, L.; Neuenschwander, M.; Bednarski, P.J.; Link, A.

Molecular Diversity 2012

Equipping in vivo Selection Systems with Tunable Stringency

• Neuenschwander, M.; Kleeb, A.C.; Kast, P.; Hilvert, D.

Protein Engineering Handbook, Volume 1 & Volume 2 2011

An N-terminal protein degradation tag enables robust selection of highly active enzymes

• Butz, M.; Neuenschwander, M.; Kast, P.; Hilvert, D.

Biochemistry 2011

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

• Lisurek, M.; Rupp, B.; Wichard, J.; Neuenschwander, M.; Von Kries, J.P.; Frank, R.; Rademann, J.; Kühne, R.

Molecular Diversity 2010

A simple selection strategy for evolving highly efficient enzymes

• Neuenschwander, M.; Butz, M.; Heintz, C.; Kast, P.; Hilvert, D.

Nature Biotechnology 2007

Metabolic engineering of a genetic selection system with tunable stringency

• Kleeb, A.C.; Edalat, M.H.; Gamper, M.; Haugstetter, J.; Giger, L.; Neuenschwander, M.; Kast, P.; Hilvert, D.

Proceedings of the National Academy of Sciences of the United States of America 2007

Rubredoxins involved in alkane oxidation

• Van Beilen, J.B.; Neuenschwander, M.; Smits, T.H.M.; Roth, C.; Balada, S.B.; Witholt, B.

Journal of Bacteriology 2002