Martin Lehmann

Claudin-4 polymerizes after a small extracellular claudin-3-like substitution

• Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Journal of Biological Chemistry 2024

Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions

• Fabian Schuhmann; Kerem Can Akkaya; Dmytro Puchkov; Martin Lehmann; Fan Liu; Weria Pezeshkian

Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies

• Ying Zhu; Kerem Can Akkaya; Julia Ruta; Nanako Yokoyama; Cong Wang; Max Ruwolt; Diogo Borges Lima; Martin Lehmann; Fan Liu

Nature Communications 2024

Canonical and non-canonical integrin-based adhesions dynamically interconvert

• Fabian Lukas; Claudia Matthaeus; Tania López-Hernández; Ines Lahmann; Nicole Schultz; Martin Lehmann; Dmytro Puchkov; Jan Pielage; Volker Haucke; Tanja Maritzen

Nature Communications 2024

OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

• Christopher Schmied; Michael Ebner; Paula Samsó Ferré; Volker Haucke; Martin Lehmann

Spatially resolved protein map of intact human cytomegalovirus virions

• Boris Bogdanow; Iris Gruska; Lars Mühlberg; Jonas Protze; Svea Hohensee; Barbara Vetter; Jens B. Bosse; Martin Lehmann; Mohsen Sadeghi; Lüder Wiebusch; Fan Liu

Nature Microbiology 2023

The Autophagy Nucleation Factor ATG9 Forms Nanoclusters with the HIV-1 Receptor DC-SIGN and Regulates Early Antiviral Autophagy in Human Dendritic Cells

• Laure Papin; Martin Lehmann; Justine Lagisquet; Ghizlane Maarifi; Véronique Robert-Hebmann; Christophe Mariller; Yann Guerardel; Lucile Espert; Volker Haucke; Fabien P. Blanchet

International Journal of Molecular Sciences 2023

A design strategy to generate a SARS‐CoV‐2 RBD vaccine that abrogates ACE2 binding and improves neutralizing antibody responses

• Christoph Ratswohl; Clara Vázquez García; Ata ul Wakeel Ahmad; Hannes Gonschior; Mikhail Lebedin; Casper Ewijn Silvis; Lisa Spatt; Cathrin Gerhard; Martin Lehmann; Leif E. Sander; Florian Kurth; Simon Olsson; Kathrin de la Rosa

European Journal of Immunology 2023

Claudin-4 polymerizes after the incorporation of just two extracellular claudin-3 residues

• Rozemarijn E. van der Veen; Jörg Piontek; Marie Bieck; Arbesa Saiti; Hannes Gonschior; Martin Lehmann

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

• Sandrine Baltzer; Timur Bulatov; Christopher Schmied; Andreas Krämer; Benedict-Tilman Berger; Andreas Oder; Ryan Walker-Gray; Christin Kuschke; Kerstin Zühlke; Jenny Eichhorst; Martin Lehmann; Stefan Knapp; John Weston; von Kries, J.P.; Roderich D. Süssmuth; Enno Klussmann

International Journal of Molecular Sciences 2022

Selective endocytosis of Ca 2+ -permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity

• Domenico Azarnia Tehran; Gaga Kochlamazashvili; Niccolò P. Pampaloni; Silvia Sposini; Jasmeet Kaur Shergill; Martin Lehmann; Natalya Pashkova; Claudia Schmidt; Delia Löwe; Hanna Napieczynska; Arnd Heuser; Andrew J. R. Plested; David Perrais; Robert C. Piper; Volker Haucke; Tanja Maritzen

Science Advances 2022

The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane

• Claudia Matthaeus; Kem A. Sochacki; Andrea M. Dickey; Dmytro Puchkov; Volker Haucke; Martin Lehmann; Justin W. Taraska

Nature Communications 2022

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

• Hannes Gonschior; Christopher Schmied; Rozemarijn Eva van der Veen; Jenny Eichhorst; Nina Himmerkus; Jörg Piontek; Dorothee Günzel; Markus Bleich; Mikio Furuse; Volker Haucke; Martin Lehmann

Nature Communications 2022

Proton-gated anion transport governs macropinosome shrinkage

• Mariia Zeziulia; Sandy Blin; Franziska W. Schmitt; Martin Lehmann; Thomas J. Jentsch

Nature Cell Biology 2022

N-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy

• Kilian Roßmann; Kerem C. Akkaya; Pascal Poc; Corentin Charbonnier; Jenny Eichhorst; Hannes Gonschior; Abha Valavalkar; Nicolas Wendler; Thorben Cordes; Benjamin Dietzek-Ivansic; Benjamin Jones; Martin Lehmann; Johannes Broichhagen

Chemical Science 2022

Enzyme self-label-bound ATTO700 in single-molecule and super-resolution microscopy

• Michael Trumpp; Anna Oliveras; Hannes Gonschior; Julia Ast; David Hodson; Petra Knaus; Martin Lehmann; Melissa Birol; Johannes Broichhagen

Chemical Communications 2022

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

• Ercu M; Michael Benedikt Mücke; Pallien T; Lajos Markó; Anastasiia Sholokh; Schächterle C; Aydin A; Kidd A; Stephan Walter; Esmati Y; Brandon J. McMurray; Daniella F Lato; Daniele Yumi Sunaga-Franze; Philip Dierks; Flores BIM; Walker-Gray R; Maolian Gong; Merticariu C; Zühlke K; Russwurm M; Liu T; Theda Ulrike Patricia Bartolomaeus; Pautz S; Schelenz S; Taube M; Napieczynska H; Heuser A; Eichhorst J; Lehmann M; Duncan C. Miller; Diecke S; Qadri F; Popova E; Langanki R; Movsesian MA; Friedrich W. Herberg; Forslund SK; Dominik N Muller; Borodina T; Maass PG; Sylvia Bähring; Hübner N; Bader M; Enno Klussmann

Circulation 2022

Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo

• Julia Ast; Alissa N. Novak; Tom Podewin; NHF Fine; Benjamin Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia Linnemann; David Hodson; Johannes Broichhagen

JACS Au 2022

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

• Martin Lehmann

Organic & Biomolecular Chemistry 2022

Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo

• Carina A. Lämmle; Adam Varady; Thorsten G. Müller; Caterina Sturtzel; Michael Riepl; Bettina Mathes; Jenny Eichhorst; Anje Sporbert; Martin Lehmann; Hans‐Georg Kräusslich; Martin Distel; Johannes Broichhagen

ChemBioChem 2021

Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

• Torsten W.B. Götz; Dmytro Puchkov; Veronika Lysiuk; Janine Lützkendorf; Alexander G. Nikonenko; Christine Quentin; Martin Lehmann; Stephan J. Sigrist; Astrid G. Petzoldt

Journal of Cell Biology 2021

Zellpermeable Nanobodys ermöglichen Zwei‐Farben‐Superauflösungsmikroskopie in lebenden, nicht transfizierten Zellen

• Anselm F. L. Schneider; Laila S. Benz; Martin Lehmann; Christian P. R. Hackenberger

Angewandte Chemie 2021

Cell‐Permeable Nanobodies Allow Dual‐Color Super‐Resolution Microscopy in Untransfected Living Cells

• Anselm F. L. Schneider; Laila S. Benz; Martin Lehmann; Christian P. R. Hackenberger

Angewandte Chemie International Edition 2021

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

• Anselm F. L. Schneider; Marina Kithil; M. Cristina Cardoso; Martin Lehmann; Christian P. R. Hackenberger

Nature Chemistry 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.

• Mecklenburg N; Izabela Kowalczyk; Witte F; Görne J; Laier A; Mamo TM; Hannes Gonschior; Lehmann M; Richter M; Sporbert A; Purfürst B; Hübner N; Annette Hammes

Development (Cambridge, England) 2021

The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses.

• Woitkuhn J; Ender A; Beuschel; Maglione M; Matkovic-Rachid T; Huang S; Lehmann M; Geiger JRP; Sigrist SJ

Journal of neurogenetics 2020

Interrogating surface <i>versus</i> intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates.

• Pascal Poc; Gutzeit VA; Julia Ast; Joon Lee; Benjamin Jones; Elisa D'Este; Mathes B; Lehmann M; David Hodson; Levitz J; Johannes Broichhagen

Chemical science 2020

Phosphodiesterase 3A and Arterial Hypertension.

• Ercu M; Lajos Markó; Schächterle C; Tsvetkov D; Cui Y; Maghsodi S; Theda Ulrike Patricia Bartolomaeus; Maass PG; Zühlke K; Gregersen N; Hübner N; Hodge R; Mühl A; Pohl B; Illas RM; Geelhaar A; Walter S; Napieczynska H; Schelenz S; Taube M; Heuser A; Anistan YM; Qadri F; Mihail Todiras; Plehm R; Popova E; Langanki R; Eichhorst J; Lehmann M; Wiesner B; Russwurm M; Sofia K Forslund; Kamer I; Müller DN; Gollasch M; Aydin A; Bähring S; Michael Bader; Luft FC; Klussmann E

Circulation 2020

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

• Claudia Matthaeus; Ines Lahmann; Severine Kunz; Wenke Jonas; Arthur Alves Melo; Martin Lehmann; Elin Larsson; Richard Lundmark; Matthias Kern; Matthias Blüher; Hannah Olschowski; Julian Kompa; Britta Brügger; Dominik N. Müller; Volker Haucke; Annette Schurmann; Carmen Birchmeier; Oliver Daumke

Proceedings of the National Academy of Sciences 2020

Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions

• Hannes Gonschior; Volker Haucke; Martin Lehmann

International Journal of Molecular Sciences 2020

Deuterated rhodamines for protein labelling in nanoscopy

• Kilian Roßmann; Kerem C. Akkaya; Corentin Charbonnier; Jenny Eichhorst; Ben Jones; Martin Lehmann; Johannes Broichhagen

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.

• Marisa M Brockmann; Maglione M; Willmes CG; Alexander Stumpf; Bouazza BA; Velasquez LM; M. Katharina Grauel; Beed P; Lehmann M; Niclas Gimber; Schmoranzer J; Stephan Sigrist; Christian Rosenmund; Dietmar Schmitz

eLife 2019

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization

• Claudia Matthäus; Xiaoming Lian; Séverine Kunz; Martin Lehmann; Cheng Zhong; Carola Bernert; Ines Lahmann; Dominik N. Müller; Maik Gollasch; Oliver Daumke

PLOS ONE 2019

Rapid active zone remodeling consolidates presynaptic potentiation.

• Mathias Böhme; Anthony William McCarthy; Andreas Grasskamp; Beuschel; Goel P; Jusyte M; Laber D; Huang S; Rey U; Petzoldt AG; Lehmann M; Göttfert F; Haghighi P; Hell SW; David Owald; Dickman D; Sigrist SJ; Alexander Matthias Walter

Nature communications 2019

Homeostatic scaling of active zone scaffolds maintains global synaptic strength

• Pragya Goel; Dominique Dufour Bergeron; Mathias A. Böhme; Luke Nunnelly; Martin Lehmann; Christopher Buser; Alexander Matthias Walter; Stephan Sigrist; Dion Dickman

Journal of Cell Biology 2019

Nanoscale coupling of endocytic pit growth and stability

• Martin Lehmann; Ilya Lukonin; Frank Noé; Jan Schmoranzer; Cecilia Clementi; Dinah Loerke; Volker Haucke

Science Advances 2019

A SEPT1-based scaffold is required for Golgi integrity and function.

• Kyungyeun Song; Claudia Gras; Capin G; Niclas Gimber; Lehmann M; Mohd S; Dmytro Puchkov; Rödiger M; Wilhelmi I; Daumke O; Schmoranzer J; Annette Schurmann; Michael Krauss

Journal of cell science 2019

Phosphorylation of the Bruchpilot N-terminus unlocks axonal transport of active zone building blocks

• Jan H. Driller; Janine Lützkendorf; Harald Depner; Matthias Siebert; Benno Kuropka; Christoph Weise; Chengji Piao; Astrid G. Petzoldt; Martin Lehmann; Ulrich Stelzl; René Zahedi; Albert Sickmann; Christian Freund; Stephan Sigrist; Markus Wahl

Journal of Cell Science 2019

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

• Anuradha Bhukel; Beuschel; Marta Maglione; Martin Lehmann; Gabor Juhász; Frank Madeo; Stephan J. Sigrist

Nature Communications 2019

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles

• Anela Vukoja; Ulises Rey; Astrid G. Petzoldt; Christoph Ott; Dennis Vollweiter; Christine Quentin; Dymtro Puchkov; Eric Reynolds; Martin Lehmann; Svea Hohensee; Stefanie Rosa; Reinhard Lipowsky; Stephan J. Sigrist; Volker Haucke

Neuron 2018

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

• Wang H; Wen-Ting Lo; Vujičić Žagar A; Federico GULLUNI; Lehmann M; Leonardo Scapozza; Haucke V; Vadas O

Molecular cell 2018

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses.

• Fulterer A; Till F M Andlauer; Ender A; Maglione M; Eyring K; Woitkuhn J; Lehmann M; Matkovic-Rachid T; Geiger JRP; Alexander Matthias Walter; Nagel KI; Sigrist SJ

Cell reports 2018

Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila.

• Hussain A; Atefeh Pooryasin; Zhang M; Loschek LF; Marco La Fortezza; Friedrich AB; Blais CM; Habibe Üçpunar; Vicente A Yépez; Lehmann M; Nicolas Gompel; Julien Gagneur; Sigrist SJ; Ilona C. Grunwald Kadow

eLife 2018

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

• Wen-Ting Lo; Vujičić Žagar A; Fabian Gerth; Lehmann M; Dmytro Puchkov; Krylova O; Freund C; Leonardo Scapozza; Vadas O; Haucke V

Developmental cell 2017

Intersectin associates with synapsin and regulates its nanoscale localization and function.

• Fabian Gerth; Jäpel M; Pechstein A; Kochlamazashvili G; Lehmann M; Dmytro Puchkov; Onofri F; Benfenati F; Nikonenko AG; Fredrich K; Oleg Shupliakov; Maritzen T; Freund C; Haucke V

Proceedings of the National Academy of Sciences of the United States of America 2017

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

• Alexander Matthias Walter; Rainer Mueller; Bassam Tawfik; Keimpe Wierda; Paulo Pinheiro; André Nadler; Anthony William McCarthy; Ziomkiewicz I; Kruse M; Reither G; Jens Rettig; Lehmann M; Haucke V; Hille B; Schultz C; Jakob Sørensen

eLife 2017

Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops.

• Gehne N; Lamik A; Lehmann M; Haseloff RF; Andjelkovic AV; Ingolf

PloS one 2017

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission.

• Johannes Schöneberg; Lehmann M; Alexander Ullrich; Posor Y; Wen-Ting Lo; Gregor Lichtner; Jan Schmoranzer; Haucke V; Noé F

Nature communications 2017