Marc Nazaré

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

• Alsalim, R.
• Lindemann, P.
• Lopez-Alberca, M. P.
• Miksche, S.
• Czechtizky, W.
• Halland, N., &
• Nazare, M.

Organic Letters 2020, 22, 7393-7396

An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

• Brennecke, B.
• Wang, Q.
• Zhang, Q.
• Hu, H. Y., &
• Nazare, M.

Angewandte Chemie-International Edition 2020, 59, 8512-8516

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

• Barone, M.
• Müller, M.
• Chiha, S.
• Ren, J.
• Albat, D.
• Soicke, A.
• Dohmen, S.
• Klein, M.
• Bruns, J.
• Dinther, M.
• Opitz, R.
• Lindemann, P.
• Beerbaum, M.
• Motzny, K.
• Roske, Y.
• Schmieder, P.
• Volkmer, R.
• Nazare, M.
• Heinemann, U.
• Oschkinat, H.
• Ten Dijke, P.
• Schmalz, H. G., &
• Kühne, R.

Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 29684-29690

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

• Sarott, R. C.
• Westphal, M. V.
• Pfaff, P.
• Korn, C.
• Sykes, D. A.
• Gazzi, T.
• Brennecke, B.
• Atz, K.
• Weise, M.
• Mostinski, Y.
• Hompluem, P.
• Koers, E.
• Miljus, T.
• Roth, N. J.
• Asmelash, H.
• Vong, M. C.
• Piovesan, J.
• Guba, W.
• Rufer, A. C.
• Kusznir, E. A.
• Huber, S.
• Raposo, C.
• Zirwes, E. A.
• Osterwald, A.
• Pavlovic, A.
• Moes, S.
• Beck, J.
• Benito-Cuesta, I.
• Grande, T.
• Esteban, S. R. D.
• Yeliseev, A.
• Drawnel, F.
• Widmer, G.
• Holzer, D.
• Wel, T.
• Mandhair, H.
• Yuan, C. Y.
• Drobyski, W. R.
• Saroz, Y.
• Grimsey, N.
• Honer, M.
• Fingerle, J.
• Gawrisch, K.
• Romero, J.
• Hillard, C. J.
• Varga, Z. V.
• Stelt, M.
• Pacher, P.
• Gertsch, J.
• McCormick, P. J.
• Ullmer, C.
• Oddi, S.
• Maccarrone, M.
• Veprintsev, D. B.
• Nazare, M.
• Grether, U., &
• Carreira, E. M.

Journal of the American Chemical Society 2020, 142, 16953-16964

Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues

• Xu, S. N.
• Zhang, Q. Y.
• Han, X. W.
• Wang, Y. L.
• Wang, X.
• Nazare, M.
• Jiang, J. D., &
• Hu, H. Y.

ACS Sensors 2020, 5, 1650-1656

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

• Mostinski, Y.
• Heynen, G.
• Lopez-Alberca, M. P.
• Paul, J.
• Miksche, S.
• Radetzki, S.
• Schaller, D.
• Shanina, E.
• Seyffarth, C.
• Kolomeets, Y.
• Ziebart, N.
• Schryver, J.
• Oestreich, S.
• Neuenschwander, M.
• Roske, Y.
• Heinemann, U.
• Rademacher, C.
• Volkamer, A.
• Kries, J. P.
• Birchmeier, W., &
• Nazare, M.

Journal of Medicinal Chemistry 2020, 63, 14780-14804

NMR quality control of fragment libraries for screening

• Sreeramulu, S.
• Richter, C.
• Kuehn, T.
• Azzaoui, K.
• Blommers, M. J. J.
• Del Conte, R.
• Fragai, M.
• Trieloff, N.
• Schmieder, P.
• Nazare, M.
• Specker, E.
• Ivanov, V.
• Oschkinat, H.
• Banci, L., &
• Schwalbe, H.

Journal of Biomolecular NMR 2020, 74, 555-563

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

• Waaler, J.
• Leenders, R. G. G.
• Sowa, S. T.
• Brinch, S. A.
• Lycke, M.
• Nieczypor, P.
• Aertssen, S.
• Murthy, S.
• Galera-Prat, A.
• Damen, E.
• Wegert, A.
• Nazare, M.
• Lehtio, L., &
• Krauss, S.

Journal of Medicinal Chemistry 2020, 63, 6834-6846

Revealing cytotoxic substructures in molecules using deep learning

• Webel, H. E.
• Kimber, T. B.
• Radetzki, S.
• Neuenschwander, M.
• Nazare, M., &
• Volkamer, A.

Journal of Computer-Aided Molecular Design 2020, 34, 731-746

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

• Marcinkowski, P.
• Hoyer, I.
• Specker, E.
• Furkert, J.
• Rutz, C.
• Neuenschwander, M.
• Sobottka, S.
• Sun, H.
• Nazare, M.
• Berchner-Pfannschmidt, U.
• Von Kries, J. P.
• Eckstein, A.
• Schülein, R., &
• Krause, G.

Thyroid 2019, 29, 111-123

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

• Schewe, M.
• Sun, H.
• Mert, U.
• Mackenzie, A.
• Pike, A. C. W.
• Schulz, F.
• Constantin, C.
• Vowinkel, K. S.
• Conrad, L. J.
• Kiper, A. K.
• Gonzalez, W.
• Musinszki, M.
• Tegtmeier, M.
• Pryde, D. C.
• Belabed, H.
• Nazare, M.
• Groot, B. L.
• Decher, N.
• Fakler, B.
• Carpenter, E. P.
• Tucker, S. J., &
• Baukrowitz, T.

Science 2019, 363, 875-880

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

• Brennecke, P.
• Rasina, D.
• Aubi, O.
• Herzog, K.
• Landskron, J.
• Cautain, B.
• Vicente, F.
• Quintana, J.
• Mestres, J.
• Stechmann, B.
• Ellinger, B.
• Brea, J.
• Kolanowski, J. L.
• Pilarski, R.
• Orzaez, M.
• Pineda-Lucena, A.
• Laraia, L.
• Nami, F.
• Zielenkiewicz, P.
• Paruch, K.
• Hansen, E.
• Kries, J. P.
• Neuenschwander, M.
• Specker, E.
• Bartunek, P.
• Simova, S.
• Lesnikowski, Z.
• Krauss, S.
• Lehtio, L.
• Bilitewski, U.
• Bronstrup, M.
• Tasken, K.
• Jirgensons, A.
• Lickert, H.
• Clausen, M. H.
• Andersen, J. H.
• Vicent, M. J.
• Genilloud, O.
• Martinez, A.
• Nazare, M.
• Fecke, W., &
• Gribbon, P.

Slas Discovery 2019, 24, 398-413

Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

• Schoene, J.
• Gazzi, T.
• Lindemann, P.
• Christmann, M.
• Volkamer, A., &
• Nazare, M.

ChemMedChem 2019, 14, 1514-1527

Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

• Zhang, Q. Y.
• Xu, S. N.
• Lai, F. F.
• Wang, Y. L.
• Zhang, N.
• Nazare, M., &
• Hu, H. Y.

Organic Letters 2019, 21, 2121-2125

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

• Plastira, I.
• Joshi, L.
• Bernhart, E.
• Schoene, J.
• Specker, E.
• Nazare, M., &
• Sattler, W.

Frontiers in Cellular Neuroscience 2019, 13, 531