Marc Nazaré

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

• Aebi J; Atz K; Ametamey SM; Benz J; Blaising J; Butini S; Campiani G; Carreira EM; Collin L; De Lago E; Gazzi T; Gertsch J; Gobbi L; Guba W; Grether U

Chimia 2024

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

• Borrega-Roman L; Hoare BL; Kosar M; Sarott RC; Patej KJ; Bouma J; Scott-Dennis M; Koers EJ; Gazzi T; Mach L; Barrondo S; Sallés J; Guba W; Kusznir E; Veprintsev DB

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB₁R).

• Mach L; Omran A; Bouma J; Radetzki S; Sykes DA; Guba W; Li X; Höffelmeyer C; Hentsch A; Gazzi T; Mostinski Y; Wasinska-Kalwa M; de Molnier F; Nazare M

Journal of medicinal chemistry 2024

DOTA-Based Plectin-1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue.

• Gazzi T; Lesina M; Wang Q; Berninger A; Radetzki S; Demir IE; Kohlmann L; Meiser W; Wilke S; von Kries JP; Algül H; Hu HY; Nazare M

Angewandte Chemie (International ed. in English) 2024

An activatable biphotonic lanthanide probe for detection of nitroreductase in live bacteria and cancer cells

• Carolina Vinagreiro; Qian Liu; Qinghua Wang; Xiang Wang; Hai-Yu Hu; Marc Nazare

Patent review of cannabinoid receptor type 2 (CB ₂ R) modulators (2016-present)

• Miroslav Kosar; Leonard Mach; Erick M. Carreira; Marc Nazaré; Pal Pacher; Uwe Grether

Expert Opinion on Therapeutic Patents 2024

Benzo‐Crown‐Ether functionalized O‐BODIPY Probes for Cations– A Selective Fluorescent Probe for Ba2+

• Thomas Schwarze; Tobias Sprenger; Marc Nazare; Hans-Jürgen Holdt; Axel Hentsch

Chemistry – A European Journal 2024

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

• Ekaterina Legchenko; Philippe Chouvarine; Fatimunnisa Qadri; Edgar Specker; Marc Nazaré; Radoslaw Wesolowski; Susann Matthes; Michael Bader; Georg Hansmannn

JACC: Basic to Translational Science 2024

DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue

• Thais Gazzi; Marina Lesina; Qinghua Wang; Alexandra Berninger; Silke Radetzki; Ihsan Ekin Demir; Larissa Kohlmann; Waldemar Meiser; Sebastian Wilke; Jens Peter von Kries; Hana Algül; Hai-Yu Hu; Marc Nazare

Angewandte Chemie 2024

Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.

• Specker E; Wesolowski R; Schütz A; Matthes S; Mallow K; Wasinska-Kalwa M; Winkler L; Oder A; Alenina N; Pleimes D; von Kries JP; Heinemann U; Bader M; Nazaré M

Journal of medicinal chemistry 2023

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.

• Yan S; Schöpe PC; Lewis J; Putzker K; Uhrig U; Specker E; von Kries JP; Lindemann P; Omran A; Sanchez-Ibarra HE; Unger A; Zischinsky ML; Klebl B; Stein U

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.

• Kücükdisli M; Bel-Abed H; Cirillo D; Lo WT; Efrém NL; Horatscheck A; Perepelittchenko L; Prokofeva P; Ehret TAL; Radetzki S; Neuenschwander M; Nazaré M

Journal of medicinal chemistry 2023

Selective and pH-Independent Detection of Ba²⁺ in Water by a Benzo-21-crown-7-Functionalized BODIPY.

• Sprenger T; Schwarze T; Müller H; Sperlich E; Holdt HJ; Nazaré M; Hentsch A; Eidner S; Kraft R; Kumke MU

Chemistry (Weinheim an der Bergstrasse, Germany) 2023

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors.

• Mucka P; Lindemann P; Bosco B; Willenbrock M; Radetzki S; Neuenschwander M; Brischetto C; Peter von Kries J; Nazaré M; Scheidereit C

Cell chemical biology 2023

Aβ Chronic Exposure Promotes an Activation State of Microglia through Endocannabinoid Signalling Imbalance.

• Scipioni L; Tortolani D; Ciaramellano F; Fanti F; Gazzi T; Sergi M; Nazaré M; Oddi S; Maccarrone M

International journal of molecular sciences 2023

CB2R agonists in the clinics: A treasure chest for treating inflammatory diseases

• Uwe Grether; Marc Nazaré

Open Access Government 2023

CB₂R ligands to treat inflammatory diabetes

• Uwe Grether; Marc Nazaré

Open Access Government 2023

First<i> in</i><i> vivo</i> fluorine-19 magnetic resonance imaging of the multiple sclerosis drug siponimod

• Starke, Ludger; Millward, Jason M.; Prinz, Christian; Sherazi, Fatima; Waiczies, Helmar; Lippert, Christoph; Nazare, Marc; Paul, Friedemann; Niendorf, Thoralf; Waiczies, Sonia

Theranostics 2023

Novel tetrazolopyridazine based MACC1 transcriptional inhibitors as promising anti-metastatic therapy

• Schope, Paul Curtis; Yan, Shixian; Kobelt, Dennis; Lewis, Joe; Putzker, Kerstin; Uhrig, Ulrike; Specker, Edgar; von Kries, Jens Peter; Dahlmann, Mathias; Sanchez-Ibarra, Hector E.; Unger, Anke; Zischinsky, Mia-Lisa; Klebl, Bert; Lindemann, Peter; Walther, Wolfgang; Nazare, Marc; Stein, Ulrike

Cancer Research 2023

Isoform-selective targeting of PI3K: time to consider new opportunities?

• Cirillo, Davide; Diceglie, Marta; Nazare, Marc

Trends in Pharmacological Sciences 2023

Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

• Jordan, Philipp; Costa, Amanda; Specker, Edgar; Popp, Oliver; Volkamer, Andrea; Piske, Regina; Obrusnik, Tessa; Kleissle, Sabrina; Stuke, Kevin; Rex, Andre; Neuenschwander, Martin; von Kries, Jens Peter; Nazare, Marc; Mertins, Phillip; Kettenmann, Helmut; Wolf, Susanne A.

Plos One 2023

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

• Lo, Wen-Ting; Belabed, Hassane; Kuecuekdisli, Murat; Metag, Juliane; Roske, Yvette; Prokofeva, Polina; Ohashi, Yohei; Horatscheck, Andre; Cirillo, Davide; Krauss, Michael; Schmied, Christopher; Neuenschwander, Martin; von Kries, Jens Peter; Medard, Guillaume; Kuster, Bernhard; Perisic, Olga; Williams, Roger L.; Daumke, Oliver; Payrastre, Bernard; Severin, Sonia; Nazare, Marc; Haucke, Volker

Nature Chemical Biology 2023

An LPAR _<b>5</b> -antagonist that reduces nociception and increases pruriception.

• Langedijk J; Araya EI; Barroso AR; Tolenaars D; Nazaré M; Belabed H; Schoene J; Chichorro JG; Oude Elferink R

Frontiers in pain research (Lausanne, Switzerland) 2022

Donor manipulation for constructing a pH sensing thermally activated delayed fluorescent probe to detect alkaliphiles

• Liu, Qian; Yang, Miao; Meng, Xiangchuan; Han, Xiaowan; Nazare, Marc; Xu, Youjun; Hu, Hai-Yu; Zhang, Qingyang

Talanta 2022

Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System

• Guberman, Monica; Kosar, Miroslav; Omran, Anahid; Carreira, Erick M.; Nazare, Marc; Grether, Uwe

Chimia 2022

Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

• Samso, Paula; Koch, Philipp A.; Posor, York; Lo, Wen-Ting; Belabed, Hassane; Nazare, Marc; Laporte, Jocelyn; Haucke, Volker

Proceedings of the National Academy of Sciences 2022

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

• Specker, Edgar; Matthes, Susann; Wesolowski, Radoslaw; Schuetz, Anja; Grohmann, Maik; Alenina, Natalia; Pleimes, Dirk; Mallow, Keven; Neuenschwander, Martin; Gogolin, Angelina; Weise, Marie; Pfeifer, Jochen; Ziebart, Nandor; Heinemann, Udo; von Kries, Jens Peter; Nazare, Marc; Bader, Michael

Journal of Medicinal Chemistry 2022

Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+Probability and CASE-3D

• Li, Xiao-Lu; Ru, Tong; Navarro-Vazquez, Armando; Lindemann, Peter; Nazare, Marc; Li, Xu-Wen; Guo, Yue-Wei; Sun, Han

Journal of Natural Products 2022

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

• Zhang, Hengxi; Modenutti, Carlos; Nekkanti, Yelha Phani Kumar; Denis, Maxime; Bermejo, Iris A. .; Lefebre, Jonathan; Che, Kateryna; Kim, Dongyoon; Kagelmacher, Marten; Kurzbach, Dennis; Nazare, Marc; Rademacher, Christoph

ACS Chemical Biology 2022

Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer

• Li, Huayi; Prever, Lorenzo; Hsu, Myriam Y.; Lo, Wen-Ting; Margaria, Jean Piero; De Santis, Maria Chiara; Zanini, Cristina; Forni, Marco; Novelli, Francesco; Pece, Salvatore; Di Fiore, Pier Paolo; Porporato, Paolo Ettore; Martini, Miriam; Belabed, Hassane; Nazare, Marc; Haucke, Volker; Gulluni, Federico; Hirsch, Emilio

Advanced Science 2022

BODIPY-Equipped Benzo-Crown-Ethers as Fluorescent Sensors for pH Independent Detection of Sodium and Potassium Ions

• Sprenger, Tobias; Schwarze, Thomas; Mueller, Holger; Sperlich, Eric; Kelling, Alexandra; Holdt, Hans-Juergen; Paul, Jerome; Riano, Vera Martos; Nazare, Marc

ChemPhotoChem 2022

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

• Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C.; Westphal, Matthias, V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L.; Miljus, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J.; Guba, Wolfgang; Alker, Andre; Rufer, Arne C.; Kusznir, Eric A.; Huber, Sylwia; Raposo, Catarina; Zirwes, Elisabeth A.; Osterwald, Anja; Pavlovic, Anto; Moes, Svenja; Beck, Jennifer; Nettekoven, Matthias; Benito-Cuesta, Irene; Grande, Teresa; Drawnel, Faye; Widmer, Gabriella; Holzer, Daniela; van der Wel, Tom; Mandhair, Harpreet; Honer, Michael; Fingerle, Jurgen; Scheffel, Joerg; Broichhagen, Johannes; Gawrisch, Klaus; Romero, Julian; Hillard, Cecilia J.; Varga, Zoltan V.; van der Stelt, Mario; Pacher, Pal; Gertsch, Jurg; Ullmer, Christoph; McCormick, Peter J.; Oddi, Sergio; Spaink, Herman P.; Maccarrone, Mauro; Veprintsev, Dmitry B.; Carreira, Erick M.; Grether, Uwe; Nazare, Marc

Chemical Science 2022

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the Lectin Langerin

• Zhang, Hengxi; Modenutti, Carlos; Nekkanti, Yelha Phani Kumar; Denis, Maxime; Bermejo, Iris A.; Lefebre, Jonathan; Che, Kateryna; Kim, Dongyoon; Kagelmacher, Marten; Kurzbach, Dennis; Nazare, Marc; Rademacher, Christoph

ACS Chemical Biology 2022

Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands

• Fernandez-Bachiller, Maria Isabel; Hwang, Songhwan; Schembri, Maria Elena; Lindemann, Peter; Guberman, Monica; Herziger, Svenja; Specker, Edgar; Matter, Hans; Will, David W.; Czech, Jorg; Wagner, Michael; Bauer, Armin; Schreuder, Herman; Ritter, Kurt; Urmann, Matthias; Wehner, Volkmar; Sun, Han; Nazare, Marc

Journal of Medicinal Chemistry 2022

Compound Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies Drug Targets

• Melder, F. Teresa, I; Lindemann, Peter; Welle, Alexander; Trouillet, Vanessa; Heissler, Stefan; Nazare, Marc; Selbach, Matthias

ChemMedChem 2022

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis

• Halland, Nis; Schmidt, Friedemann; Weiss, Tilo; Li, Ziyu; Czech, Jorg; Saas, Joachim; Ding-Pfennigdorff, Danping; Dreyer, Matthias K.; Strubing, Carsten; Nazare, Marc

Journal of Medicinal Chemistry 2022

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

• Hengxi Zhang; Carlos Modenutti; N. Y. Phani Kumar; Maxime Denis; Iris Bermejo; Jonathan Lefebre; Kateryna Che; Dongyoon Kim; Marten Kagelmacher; Dennis Kurzbach; Marc Nazare; Christoph Rademacher

OpenAlex 2022

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

• Hengxi Zhang; Carlos Modenutti; N. Y. Phani Kumar; Maxime Denis; Iris Bermejo; Jonathan Lefebre; Kateryna Che; Dongyoon Kim; Marten Kagelmacher; Dennis Kurzbach; Marc Nazare; Christoph Rademacher

OpenAlex 2022

In vivo detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy

• Prinz, Christian; Starke, Ludger; Millward, Jason M.; Fillmer, Ariane; Delgado, Paula Ramos; Waiczies, Helmar; Pohlmann, Andreas; Rothe, Michael; Nazare, Marc; Paul, Friedemann; Niendorf, Thoralf; Waiczies, Sonia

Theranostics 2021

Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010

• Brennecke, Benjamin; Gazzi, Thais; Atz, Kenneth; Fingerle, Jurgen; Kuner, Pascal; Schindler, Torsten; de Weck, Guy; Nazare, Marc; Grether, Uwe

Pharmaceutical Patent Analyst 2021

Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

• Carter, David M.; Specker, Edgar; Malecki, Piotr H.; Przygodda, Jessica; Dudaniec, Krystyna; Weiss, Manfred S.; Heinemann, Udo; Nazare, Marc; Gohlke, Ulrich

Journal of Medicinal Chemistry 2021

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

• Leenders, Ruben G. G.; Brinch, Shoshy Alam; Sowa, Sven T.; Amundsen-Isaksen, Enya; Galera-Prat, Albert; Murthy, Sudarshan; Aertssen, Sjoerd; Smits, Johannes N.; Nieczypor, Piotr; Damen, Eddy; Wegert, Anita; Nazare, Marc; Lehtio, Lari; Waaler, Jo; Krauss, Stefan

Journal of Medicinal Chemistry 2021

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

• Bonnekoh, Hanna; Vera, Carolina; Abad-Perez, Angela; Radetzki, Silke; Neuenschwander, Martin; Specker, Edgar; Mahnke, Niklas Amadeus; Frischbutter, Stefan; Latz, Eicke; Nazare, Marc; Kries, Jens V.; Maurer, Marcus; Scheffel, Joerg; Krause, Karoline

Clinical and Translational Allergy 2021

Functional Imaging Using Fluorine (F-19) MR Methods: Basic Concepts

• Waiczies, Sonia; Prinz, Christian; Starke, Ludger; Millward, Jason M.; Delgado, Paula Ramos; Rosenberg, Jens; Nazare, Marc; Waiczies, Helmar; Pohlmann, Andreas; Niendorf, Thoralf

Methods in Molecular Biology 2021

Structural Basis for Gating of the Two-Pore Domain K+ (K-2P) Channels TASK-1 and TALK-2

• Schewe, Marcus; Riel, Elena B.; Rinne, Susanne; Kopec, Wojciech; Langer, Jan; Lindemann, Peter; Juers, Bjoern C.; Nazare, Marc; de Groot, Bert L.; Decher, Niels; Baukrowitz, Thomas

Biophysical Journal 2021

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

• Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazare, Marc

Bioconjugate Chemistry 2021

Pentafluorosulfanyl (SF₅) as a Superior <SUP>19</SUP>F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives

• Prinz, Christian; Starke, Ludger; Ramspoth, Tizian-Frank; Kerkering, Janis; Riano, Vera Martos; Paul, Jerome; Neuenschwander, Martin; Oder, Andreas; Radetzki, Silke; Adelhoefer, Siegfried; Delgado, Paula Ramos; Aravina, Mariya; Millward, Jason M.; Fillmer, Ariane; Paul, Friedemann; Siffrin, Volker; Von Kries, Jens-Peter; Niendorf, Thoralf; Nazare, Marc; Waiczies, Sonia

ACS Sensors 2021

Generation of a TR-FRET-based assay for the determination of cannabinoid CB1 receptor ligand binding kinetics

• Borrega, Leire; Hoare, Brad; Gazzi, Thais; Nazare, Marc; Grether, Uwe; Sykes, David; Veprintsev, Dmitry

British Journal of Pharmacology 2021

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

• Waaler, Jo; Leenders, Ruben G. G.; Sowa, Sven T.; Brinch, Shoshy Alam; Lycke, Max; Nieczypor, Piotr; Aertssen, Sjoerd; Murthy, Sudarshan; Galera-Prat, Albert; Damen, Eddy; Wegert, Anita; Nazare, Marc; Lehtio, Lari; Krauss, Stefan

Journal of Medicinal Chemistry 2020

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

• Barone, Matthias; Mueller, Matthias; Chiha, Slim; Ren, Jiang; Albat, Dominik; Soicke, Arne; Dohmen, Stephan; Klein, Marco; Bruns, Judith; van Dinther, Maarten; Opitz, Robert; Lindemann, Peter; Beerbaum, Monika; Motzny, Kathrin; Roske, Yvette; Schmieder, Peter; Volkmer, Rudolf; Nazare, Marc; Heinemann, Udo; Oschkinat, Hartmut; ten Dijke, Peter; Schmalz, Hans-Guenther; Kuehne, Ronald

Proceedings of the National Academy of Sciences 2020

Development and application of a kinetic ligand binding assay for the cannabinoid receptor 1 using resonance energy transfer approaches

• Hoare, Bradley; Sykes, David; Gazzi, Thais; Nazare, Marc; Grether, Uwe; Veprintsev, Dmitry

British Journal of Pharmacology 2020

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement

• Mostinski, Yelena; Heynen, Guus J. J. E.; Lopez-Alberca, Maria Pascual; Paul, Jerome; Miksche, Sandra; Radetzki, Silke; Schaller, David; Shanina, Elena; Seyffarth, Carola; Kolomeets, Yuliya; Ziebart, Nandor; de Schryver, Judith; Oestreich, Sylvia; Neuenschwander, Martin; Roske, Yvette; Heinemann, Udo; Rademacher, Christoph; Volkamer, Andrea; von Kries, Jens Peter; Birchmeier, Walter; Nazare, Marc

Journal of Medicinal Chemistry 2020

Revealing cytotoxic substructures in molecules using deep learning

• Webel, Henry E.; Kimber, Talia B.; Radetzki, Silke; Neuenschwander, Martin; Nazare, Marc; Volkamer, Andrea

Journal of Computer-Aided Molecular Design 2020

NMR quality control of fragment libraries for screening

• Sreeramulu, Sridhar; Richter, Christian; Kuehn, Till; Azzaoui, Kamal; Blommers, Marcel Jules Jose; Del Conte, Rebecca; Fragai, Marco; Trieloff, Nils; Schmieder, Peter; Nazare, Marc; Specker, Edgar; Ivanov, Vladimir; Oschkinat, Hartmut; Banci, Lucia; Schwalbe, Harald

Journal of Biomolecular NMR 2020

Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

• Sarott, Roman C.; Westphal, Matthias, V; Pfaff, Patrick; Korn, Claudia; Sykes, David A.; Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Weise, Marie; Mostinski, Yelena; Hompluem, Pattarin; Koers, Eline; Miljus, Tamara; Roth, Nicolas J.; Asmelash, Hermon; Vong, Man C.; Piovesan, Jacopo; Guba, Wolfgang; Rufer, Arne C.; Kusznir, Eric A.; Huber, Sylwia; Raposo, Catarina; Zirwes, Elisabeth A.; Osterwald, Anja; Pavlovic, Anto; Moes, Svenja; Beck, Jennifer; Benito-Cuesta, Irene; Grande, Teresa; de Martin Esteban, Samuel Ruiz; Yeliseev, Alexei; Drawnel, Faye; Widmer, Gabriella; Holzer, Daniela; van der Wel, Tom; Mandhair, Harpreet; Yuan, Cheng-Yin; Drobyski, William R.; Saroz, Yurii; Grimsey, Natasha; Honer, Michael; Fingerle, Juergen; Gawrisch, Klaus; Romero, Julian; Hillard, Cecilia J.; Varga, Zoltan V.; van der Stelt, Mario; Pacher, Pal; Gertsch, Juerg; McCormick, Peter J.; Ullmer, Christoph; Oddi, Sergio; Maccarrone, Mauro; Veprintsev, Dmitry B.; Nazare, Marc; Grether, Uwe; Carreira, Erick M.

Journal of the American Chemical Society 2020

Diverse chemotypes drive biased signaling by cannabinoid receptors

• Miljuš T; Heydenreich FM; Gazzi T; Kimbara A; Rogers-Evans M; Nettekoven M; Zirwes E; Osterwald A; Rufer AC; Ullmer C; Guba W; Le Gouill C; Veprintsev DB

Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues

• Shengnan Xu; Qingyang Zhang; Xiaowan Han; Yali Wang; Xiang Wang; Marc Nazare; Jian-Dong Jiang; Hai-Yu Hu

ACS Sensors 2020

Eine aktivierbare Lanthanoid‐Lumineszenzsonde für die zeitgesteuerte Detektion von Nitroreduktase in lebenden Bakterien

• Benjamin Brennecke; Qinghua Wang; Qingyang Zhang; Hai‐Yu Hu; Marc Nazaré

Angewandte Chemie 2020

Back Cover: An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria (Angew. Chem. Int. Ed. 22/2020)

• Benjamin Brennecke; Qinghua Wang; Qingyang Zhang; Hai‐Yu Hu; Marc Nazaré

Angewandte Chemie International Edition 2020

Rücktitelbild: Eine aktivierbare Lanthanoid‐Lumineszenzsonde für die zeitgesteuerte Detektion von Nitroreduktase in lebenden Bakterien (Angew. Chem. 22/2020)

• Benjamin Brennecke; Qinghua Wang; Qingyang Zhang; Hai‐Yu Hu; Marc Nazaré

Angewandte Chemie 2020

A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles

• Alsalim, Rana; Lindemann, Peter; Lopez-Alberca, Maria Pascual; Miksche, Sandra; Czechtizky, Werngard; Halland, Nis; Nazare, Marc

Organic Letters 2020

An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria

• Brennecke, Benjamin; Wang, Qinghua; Zhang, Qingyang; Hu, Hai-Yu; Nazare, Marc

Angewandte Chemie International Edition 2020

Preclinical efficacy of NLRP3 small molecule inflammasome inhibitors: Implications for future treatment of autoinflammatory syndromes

• Abad-Perez, A.; Frischbutter, S.; Mahnke, N. A.; Kries, J. V.; Nazare, M.; Maurer, M.; Scheffel, J.; Krause, K.

Experimental Dermatology 2019

Topical inflammasome inhibition-a novel treatment strategy for contact dermatitis

• Bonnekoh, H.; Vera, C.; Abad-Perez, A.; van Kries, J.; Nazare, M.; Mahnke, N. A.; Maurer, M.; Scheffel, J.; Krause, K.

Experimental Dermatology 2019

Probing 2<i>H</i>-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

• Schoene, Jens; Gazzi, Thais; Lindemann, Peter; Christmann, Mathias; Volkamer, Andrea; Nazare, Marc

ChemMedChem 2019

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

• Marc Nazaré

Frontiers in Cellular Neuroscience 2019

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

• Marcinkowski, Patrick; Hoyer, Inna; Specker, Edgar; Furkert, Jens; Rutz, Claudia; Neuenschwander, Martin; Sobottka, Sebastian; Sun, Han; Nazare, Marc; Berchner-Pfannschmidt, Utta; Von kries, Jens Peter; Eckstein, Anja; Schuelein, Ralf; Krause, Gerd

Thyroid 2019

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

• Brennecke, Philip; Rasina, Dace; Aubi, Oscar; Herzog, Katja; Landskron, Johannes; Cautain, Bastien; Vicente, Francisca; Quintana, Jordi; Mestres, Jordi; Stechmann, Bahne; Ellinger, Bernhard; Brea, Jose; Kolanowski, Jacek L.; Pilarski, Radoslaw; Orzaez, Mar; Pineda-Lucena, Antonio; Laraia, Luca; Nami, Faranak; Zielenkiewicz, Piotr; Paruch, Kamil; Hansen, En; von Kries, Jens P.; Neuenschwander, Martin; Specker, Edgar; Bartunek, Petr; Simova, Sarka; Lesnikowski, Zbigniew; Krauss, Stefan; Lehtio, Lari; Bilitewski, Ursula; Broenstrup, Mark; Tasken, Kjetil; Jirgensons, Aiprs; Lickert, Heiko; Clausen, Mads H.; Andersen, Jeanette H.; Vicent, Maria J.; Genilloud, Olga; Martinez, Aurora; Nazare, Marc; Fecke, Wolfgang; Gribbon, Philip

SLAS Discovery: Advancing Life Sciences R & D 2019

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

• Schewe, Marcus; Sun, Han; Mert, Umit; Mackenzie, Alexandra; Pike, Ashley C. W.; Schulz, Friederike; Constantin, Cristina; Vowinkel, Kirsty S.; Conrad, Linus J.; Kiper, Aytug K.; Gonzalez, Wendy; Musinszki, Marianne; Tegtmeier, Marie; Pryde, David C.; Belabed, Hassane; Nazare, Marc; de Groot, Bert L.; Decher, Niels; Fakler, Bernd; Carpenter, Elisabeth P.; Tucker, Stephen J.; Baukrowitz, Thomas

Science 2019

Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen

• Zhang, Qingyang; Xu, Shengnan; Lai, Fangfang; Wang, Yali; Zhang, Na; Nazare, Marc; Hu, Hai-Yu

Organic Letters 2019

Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin

• Wenskowsky, Lea; Schreuder, Herman; Derdau, Volker; Matter, Hans; Volkmar, Julia; Nazare, Marc; Opatz, Till; Petry, Stefan

Angewandte Chemie International Edition 2018

A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging

• Liu, Yun; Zhang, Leilei; Nazare, Marc; Yao, Qingqiang; Hu, Hai-Yu

Acta Pharmaceutica Sinica B 2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

• Ruess, Dietrich A.; Heynen, Guus J.; Ciecielski, Katrin J.; Ai, Jiaoyu; Berninger, Alexandra; Kabacaoglu, Derya; Goerguelue, Kivanc; Dantes, Zahra; Woermann, Sonja M.; Diakopoulos, Kalliope N.; Karpathaki, Angeliki F.; Kowalska, Marlena; Kaya-Aksoy, Ezgi; Song, Liang; van der Laan, Eveline A. Zeeuw; Lopez-Alberca, Maria P.; Nazare, Marc; Reichert, Maximilian; Saur, Dieter; Erkan, Mert M.; Hopt, Ulrich T.; Sainz, Bruno, Jr.; Birchmeier, Walter; Schmid, Roland M.; Lesina, Marina; Alguel, Hana

Nature Medicine 2018

Allosteric Inhibition of a Mammalian Lectin

• Aretz, Jonas; Anumala, Upendra R.; Fuchsberger, Felix F.; Molavi, Narges; Ziebart, Nandor; Zhang, Hengxi; Nazare, Marc; Rademacher, Christoph

Journal of the American Chemical Society 2018

In Vivo Imaging of MMP-13 Activity Using a Specific Polymer-FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy

• Duro-Castano, Aroa; Lim, Ngee Han; Tranchant, Isabelle; Amoura, Mehdi; Beau, Fabrice; Wieland, Heike; Kingler, Otmar; Herrmann, Matthias; Nazare, Marc; Plettenburg, Oliver; Dive, Vincent; Vicent, Maria J.; Nagase, Hideaki

Advanced Functional Materials 2018

A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System

• Schoene, Jens; Bel Abed, Hassen; Schmieder, Peter; Christmann, Mathias; Nazare, Marc

Chemistry - A European Journal 2018

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

• Schulze, Jessica; Baukmann, Hannes; Wawrzinek, Robert; Fuchsberger, Felix F.; Specker, Edgar; Aretz, Jonas; Nazare, Marc; Rademacher, Christoph

ACS Chemical Biology 2018

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

• Klein, Wolfgang; Rutz, Claudia; Eckhard, Jamina; Provinciael, Becky; Specker, Edgar; Neuenschwander, Martin; Kleinau, Gunnar; Scheerer, Patrick; von Kries, Jens-Peter; Nazare, Marc; Vermeire, Kurt; Schuelein, Ralf

Plos One 2018

Novel strategy for the preparation of 3-perfluoroalkylated-2H-indazole derivatives

• Abed, Hassen Bel; Weissing, Nils; Schoene, Jens; Paulus, Jannik; Sewald, Norbert; Nazare, Marc

Tetrahedron Letters 2018

Regulation of Two-pore Domain K plus Channels by Natural Effectors and Pharmacological Agents

• Schewe, M.; Schulz, F.; Mert, U.; Sun, H.; Belabed, H.; Musinszki, M.; Koehler, T.; Tegtmeier, M.; Nazare, M.; Carpenter, E. P.; Tucker, S. J.; Baukrowitz, T.

Acta Physiologica 2017

A straightforward approach to N-substituted-2H-indazol-2-amines through reductive cyclization

• Schoene, Jens; Abed, Hassen Bel; Christmann, Mathias; Nazare, Marc

Tetrahedron Letters 2017

Novel compounds targeting microglial nitric oxide release

• Jordan, P.; Wolf, S. A.; Specker, E.; Nazare, M.; Kettenmann, H.

Glia 2017

N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals

• Marc Nazaré

Official Gazette of the United States Patent and Trademark Office Patents 2017

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

• Carter, David M.; Specker, Edgar; Przygodda, Jessica; Neuenschwander, Martin; von Kries, Jens Peter; Heinemann, Udo; Nazare, Marc; Gohlke, Ulrich

SLAS Discovery: Advancing Life Sciences R & D 2017

Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances

• Han Sun; André Horatscheck; Vera Martos; Max Bartetzko; Ulrike Uhrig; Dieter Lentz; Peter Schmieder; Marc Nazaré

Angewandte Chemie 2017

A conserved drug-binding site controls the selectivity filter gate in K2P K+ channels

• Schewer, M.; Schulz, F.; Mert, Ue.; Sun, H.; Koehler, T.; Tegtmeier, M.; Musinszki, M.; Belabed, H.; Nazare, M.; Tucker, S. J.; Baukrowitz, T.

Acta Physiologica 2017

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

• Griger, Joscha; Schneider, Robin; Lahmann, Ines; Schoewel, Verena; Keller, Charles; Spuler, Simone; Nazare, Marc; Birchmeier, Carmen

eLife 2017

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach

• Anumala, Upendra Rao; Waaler, Jo; Nkizinkiko, Yves; Ignatev, Alexander; Lazarow, Katina; Lindemann, Peter; Olsen, Petter Angell; Murthy, Sudarshan; Obaii, Ezeogo; Majouga, Alexander G.; Leonov, Sergey; von Kries, Jens Peter; Lehtio, Lari; Krauss, Stefan; Nazare, Marc

Journal of Medicinal Chemistry 2017

Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures

• Geiger, Michel-Andreas; Orwick-Rydmark, Marcella; Marker, Katharina; Franks, W. Trent; Akhmetzyanov, Dmitry; Stoppler, Daniel; Zinke, Maximilian; Specker, Edgar; Nazare, Marc; Diehl, Anne; van Rossum, Barth-Jan; Aussenac, Fabien; Prisner, Thomas; Akbey, Umit; Oschkinat, Hartmut

Physical Chemistry Chemical Physics 2016

5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors

• Robertson, Mark J.; Horatscheck, Andre; Sauer, Samantha; von Kleist, Lisa; Baker, Jennifer R.; Stahlschmidt, Wiebke; Nazare, Marc; Whiting, Ainslie; Chau, Ngoc; Robinson, Phillip J.; Haucke, Volker; McCluskey, Adam

Organic & Biomolecular Chemistry 2016

Pyrazole derivatives and their use as LPAR5 antagonists

• Marc Nazaré

Official Gazette of the United States Patent and Trademark Office Patents 2016

ChemInform Abstract: Organophosphorus-Mediated N-N Bond Formation: Facile Access to 3-Amino-2H-indazoles

• Hassen Bel Abed; Jens Schoene; Mathias Christmann; Marc Nazare

ChemInform 2016

Pharmacological targeting of human tryptophan hydroxylase - novel inhibitors for the treatment of serotonin-related diseases

• Matthes, S.; Specker, E.; Schuetz, A.; Grohmann, M.; von Kries, J.; Nazare, M.; Bader, M.

Naunyn-Schmiedeberg's Archives of Pharmacology 2016

Modulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5

• Kozian, Detlef H.; von Haeften, Elisabeth; Joho, Sabrina; Czechtizky, Werngard; Anumala, Upendra R.; Roux, Pascale; Dudda, Angela; Evers, Andreas; Nazare, Marc

Chembiochem 2016

Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles

• Abed, Hassen Bel; Schoene, Jens; Christmann, Mathias; Nazare, Marc

Organic & Biomolecular Chemistry 2016

Chemical fragment arrays for rapid druggability assessment

• Aretz, J.; Kondoh, Y.; Honda, K.; Anumala, U. R.; Nazare, M.; Watanabe, N.; Osada, H.; Rademacher, C.

Chemical Communications 2016

DEVELOPMENT OF IMAGING AGENTS FOR THE VISUALISATION OF CARTILAGE IN VIVO

• Lim, N. H.; Hu, H.; Nazare, M.; Plettenburg, O.; Nagase, H.; Schultz, C.

Osteoarthritis and Cartilage 2015

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]sulfonamides as Highly Active and Selective SGK1 Inhibitors

• Halland, Nis; Schmidt, Friedemann; Weiss, Tilo; Saas, Joachim; Li, Ziyu; Czech, Joerg; Dreyer, Matthias; Hofmeister, Armin; Mertsch, Katharina; Dietz, Uwe; Struebing, Carsten; Nazare, Marc

ACS Medicinal Chemistry Letters 2015

DOTAM Derivatives as Active Cartilage-Targeting Drug Carriers for the Treatment of Osteoarthritis

• Hu, Hai-Yu; Lim, Ngee-Han; Ding-Pfennigdorff, Danping; Saas, Joachim; Wendt, K. Ulrich; Ritzeler, Olaf; Nagase, Hideaki; Plettenburg, Oliver; Schultz, Carsten; Nazare, Marc

Bioconjugate Chemistry 2015

In vivo visualization of osteoarthritic hypertrophic lesions

• Hu, Hai-Yu; Lim, Ngee-Han; Juretschke, Hans-Paul; Ding-Pfennigdorff, Danping; Florian, Peter; Kohlmann, Markus; Kandira, Abdullah; von Kries, Jens Peter; Saas, Joachim; Rudolphi, Karl A.; Wendt, K. Ulrich; Nagase, Hideaki; Plettenburg, Oliver; Nazare, Marc; Schultz, Carsten

Chemical Science 2015

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

• Wilde, Felix; Specker, Edgar; Neuenschwander, Martin; Nazare, Marc; Bodtke, Anja; Link, Andreas

Molecular Diversity 2014

Quinoline-carboxamide derivatives as P2Y12 antagonists

• Marc Nazare

Official Gazette of the United States Patent and Trademark Office Patents 2014

N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

• Boldron, Christophe; Besse, Angelina; Bordes, Marie-Francoise; Tissandie, Stephanie; Yvon, Xavier; Gau, Benjamin; Badorc, Alain; Rousseaux, Tristan; Barre, Guillaume; Meneyrol, Jerome; Zech, Gernot; Nazare, Marc; Fossey, Valerie; Pflieger, Anne-Marie; Bonnet-Lignon, Sandrine; Millet, Laurence; Briot, Christophe; Dol, Frederique; Herault, Jean-Pascal; Savi, Pierre; Lassalle, Gilbert; Delesque, Nathalie; Herbert, Jean-Marc; Bono, Francoise

Journal of Medicinal Chemistry 2014

Targeting Platelet G Protein-Coupled Receptors for Antithrombotic Therapy

• Falker, Knut; Nazare, Marc; Wonerow, Peter; Kozian, Detlef H.

Drug Development Research 2013

Identification of High-Affinity P2Y(12) Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone

• Zech, Gernot; Hessler, Gerhard; Evers, Andreas; Weiss, Tilo; Florian, Peter; Just, Melitta; Czech, Joerg; Czechtizky, Werngard; Goerlitzer, Jochen; Ruf, Sven; Kohlmann, Markus; Nazare, Marc

Journal of Medicinal Chemistry 2012

Selective non-lipid modulator of LPA5 activity in human platelets

• Kozian, Detlef H.; Evers, Andreas; Florian, Peter; Wonerow, Peter; Joho, Sabrina; Nazare, Marc

Bioorganic & Medicinal Chemistry Letters 2012

Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes

• Marc Nazaré; Hans Matter; David W. Will; Michael Wagner; Matthias Urmann; Jörg Czech; Herman Schreuder; Armin Bauer; Kurt Ritter; Volkmar Wehner

Angewandte Chemie 2011

Innenrücktitelbild: Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes (Angew. Chem. 4/2012)

• Marc Nazaré; Hans Matter; David W. Will; Michael Wagner; Matthias Urmann; Jörg Czech; Herman Schreuder; Armin Bauer; Kurt Ritter; Volkmar Wehner

Angewandte Chemie 2011

ChemInform Abstract: A General and Mild Domino Approach to Substituted 1-Aminoindoles

• Nis Halland; Marc Nazare; Jorge Alonso; Omar R'kyek; Andreas Lindenschmidt

ChemInform 2011

ChemInform Abstract: A Direct, Regioselective Palladium-Catalyzed Synthesis of N-Substituted Benzimidazoles and Imidazopyridines

• Jorge Alonso; Nis Halland; Marc Nazare; Omar R'kyek; Matthias Urmann; Andreas Lindenschmidt

ChemInform 2011

A Direct, Regioselective Palladium-Catalyzed Synthesis of N-Substituted Benzimidazoles and Imidazopyridines

• Alonso, Jorge; Halland, Nis; Nazare, Marc; R'kyek, Omar; Urmann, Matthias; Lindenschmid, Andreas

European Journal of Organic Chemistry 2011

A general and mild domino approach to substituted 1-aminoindoles

• Halland, Nis; Nazare, Marc; Alonso, Jorge; R'kyek, Omar; Lindenschmidt, Andreas

Chemical Communications 2011

ChemInform Abstract: Enantiospecific Synthesis of the (9S,18R)-Diastereomer of the Leukocyte Adhesion Inhibitor Cyclamenol A

• Marc Nazare; Herbert Waldmann

ChemInform 2010

ChemInform Abstract: Synthesis of the (9S,18R) Diastereomer of Cyclamenol A

• Marc Nazare; Herbert Waldmann

ChemInform 2010

A General Palladium-Catalyzed Sonogashira Coupling of Aryl and Heteroaryl Tosylates

• R'kyek, Omar; Halland, Nis; Lindenschmidt, Andreas; Alonso, Jorge; Lindemann, Peter; Urmann, Matthias; Nazare, Marc

Chemistry - A European Journal 2010

ChemInform Abstract: Synthesis of the (9S,18R)-seco Acid of the Leukocyte Adhesion Inhibitor Cyclamenol A

• Marc Nazare; Herbert Waldmann

ChemInform 2010

ChemInform Abstract: A General Palladium-Catalyzed Sonogashira Coupling of Aryl and Heteroaryl Tosylates

• Omar R'kyek; Nis Halland; Andreas Lindenschmidt; Jorge Alonso; Peter Lindemann; Matthias Urmann; Marc Nazare

ChemInform 2010

ChemInform Abstract: A General and Mild Palladium-Catalyzed Domino Reaction for the Synthesis of 2H-Indazoles

• Nis Halland; Marc Nazare; Omar R'kyek; Jorge Alonso; Matthias Urmann; Andreas Lindenschmidt

ChemInform 2010

A General and Mild Palladium-Catalyzed Domino Reaction for the Synthesis of 2H-Indazoles

• Nis Halland; Marc Nazaré; Omar R'kyek; Jorge Alonso; Matthias Urmann; Andreas Lindenschmidt

Angewandte Chemie 2009

Evidence for CCl/CBr⋅⋅⋅π Interactions as an Important Contribution to Protein-Ligand Binding Affinity

• Hans Matter; Marc Nazaré; Stefan Güssregen; David W. Will; Herman Schreuder; Armin Bauer; Matthias Urmann; Kurt Ritter; Michael Wagner; Volkmar Wehner

Angewandte Chemie 2009

Structural requirements for factor xa inhibition by 3-oxybenzamides with neutral P1 substituents: Combining X-ray crystallography, 3D-QSAR, and tailored scoring functions

• Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V

Journal of Medicinal Chemistry 2005

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: A study combining structure-activity relationship and X-ray crystallography

• Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V

Journal of Medicinal Chemistry 2005

Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand

• Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V

Bioorganic & Medicinal Chemistry Letters 2004

Novel Factor Xa Inhibitors Based on a 2-Carboxyindole Scaffold: SAR of P4 Substituents in Combination with a Neutral P1 Ligand

• Marc Nazare; et al. et al.

ChemInform 2004

Factor Xa Inhibitors Based on a 2-Carboxyindole Scaffold: SAR of Neutral P1 Substituents

• Marc Nazare; et al. et al.

ChemInform 2004

Eine flexible, palladiumkatalysierte Indol- und Azaindolsynthese durch direkte Anellierung von Chloranilinen und Chloraminopyridinen mit Ketonen

• Marc Nazaré; Claudia Schneider; Andreas Lindenschmidt; David William Will

Angewandte Chemie 2004

A Flexible, Palladium-Catalyzed Indole and Azaindole Synthesis by Direct Annulation of Chloroanilines and Chloroaminopyridines with Ketones

• Marc Nazare; Claudia Schneider; Andreas Lindenschmidt; David William Will

ChemInform 2004

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand

• Nazare, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW

Bioorganic & Medicinal Chemistry Letters 2004

Flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones

• Nazare, M; Schneider, C; Lindenschmidt, A; Will, DW

Angewandte Chemie International Edition 2004

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral PI substituents

• Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V

Bioorganic & Medicinal Chemistry Letters 2004

Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A

• Nazare, M; Waldmann, H

Chemistry - A European Journal 2001

Enantiospecific synthesis of the (95,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol a

• Nazaré, M.; Waldmann, H.

Chemistry - A European Journal 2001

Synthese des (9S,18R)-Diastereomers von Cyclamenol A

• Marc Nazaré; Herbert Waldmann

Angewandte Chemie 2000

Synthesis of the (9S,18R) diastereomer of cyclamenol A

• Nazare, M; Waldmann, H

Angewandte Chemie International Edition 2000

Synthesis of the (9S, 18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol A

• Nazare, M; Waldmann, H

Tetrahedron Letters 2000

Efficient enantioselective synthesis of a beta-hydroxyepoxide building block for the construction of macrocyclic natural products

• Schlede, U; Nazare, M; Waldmann, H

Tetrahedron Letters 1998

Halogen…π Interactions as Important Contributors to Binding Affinity in Medicinal Chemistry

• Marc Nazaré

Use of substituted heterocyclic compounds for treating disease associated with genotoxic stress-induced I kappa B kinase/nuclear factor kappa-light-chain-enhancer of activated B cells activation which is cancer

• Marc Nazaré

Use of substituted heterocyclic compounds for treating a subject afflicted by hyperthyroidism or thyroid disease including Grave's disease, Grave's ophthalmopathy, Grave's dermopathy or thyroid cancer

• Marc Nazaré

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45

• Marc Nazaré

Composition to identify compound of interest comprises fluorescent-labeled fatty acid whose fatty acid part binds to fatty acid binding compound, and fluorescent part and compound interact to elicit Forster resonance energy transfer effects

• Marc Nazaré

New xanthine derivatives are tryptophan hydroxylases inhibitors used to treat e.g. bone diseases, systemic sclerosis, gastrointestinal diseases, cancer, vascular diseases, inflammatory, metabolic diseases and psychiatric diseases

• Marc Nazaré

New N-(4-(azaindazol-6-yl)-phenyl)-sulfonamide compound used in treating e.g. diabetes, cardiovascular diseases, fibrosis, inflammation, epilepsy, pain, tumors, cerebral infarctions, osteoarthritis, obesity, dyslipidemia, gout and tinnitus

• Marc Nazaré

New substituted triazole derivatives are tankyrase-1 inhibitors useful for treating or preventing e.g. non-regenerative wound healing, viral infection, dermal, renal, liver or myocardial fibrosis, or aberrant systemic glucose metabolism

• Marc Nazaré

New xanthine derivatives are tryptophan hydroxylase inhibitor, used to treat serotonin-related diseases or disorders e.g. osteoporosis, osteoporosis pseudoglioma syndrome, osteopenia, diarrhea, emesis, and peripheral artery disease

• Marc Nazaré