[Translate to Deutsch:] portrait jens von kries

Dr.

Jens Peter von Kries

Head of Screening Unit

Chemische Biologie


Screening-Unit


FMP

Kurzvita

Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.

  • Specker E; Wesolowski R; Schütz A; Matthes S; Mallow K; Wasinska-Kalwa M; Winkler L; Oder A; Alenina N; Pleimes D; von Kries JP; Heinemann U; Bader M; Nazaré M

Journal of medicinal chemistry 2023

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Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.

  • Yan S; Schöpe PC; Lewis J; Putzker K; Uhrig U; Specker E; von Kries JP; Lindemann P; Omran A; Sanchez-Ibarra HE; Unger A; Zischinsky ML; Klebl B; Stein U

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.

  • Aguirre T; Dornan GL; Hostachy S; Neuenschwander M; Seyffarth C; Haucke V; Schütz A; von Kries JP; Fiedler D

eLife 2023

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Small Molecules Targeting Human UDP-GlcNAc 2-Epimerase.

  • Gorenflos López JL; Dornan GL; Boback N; Neuenschwander M; Oder A; Kemnitz-Hassanin K; Schmieder P; Specker E; Asikoglu HC; Oberdanner C; Hackenberger CPR

Chembiochem : a European journal of chemical biology 2023

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Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.

  • Kücükdisli M; Bel-Abed H; Cirillo D; Lo WT; Efrém NL; Horatscheck A; Perepelittchenko L; Prokofeva P; Ehret TAL; Radetzki S; Neuenschwander M; Nazaré M

Journal of medicinal chemistry 2023

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7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

  • Zink C; Witzinger L; Keller A; Hadamek K; Bothe S; Neuenschwander M; Villmann C; von Kries JP; Schindelin H; Jeanclos E; Gohla A
online lesen

Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection.

  • Mehboob R; von Kries JP; Ehsan K; Almansouri M; Bamaga AK

Frontiers in neurology 2023

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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

  • Aguirre T; Dornan GL; Hostachy S; Neuenschwander M; Seyffarth C; Haucke V; Schütz A; von Kries JP; Fiedler D
online lesen

Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation.

  • Renikunta HV; Lazarow K; Gong Y; Shukla PC; Nageswaran V; Giral H; Kratzer A; Opitz L; Engel FB; Haghikia A; Costantino S; Paneni F; von Kries JP; Jakob P

iScience 2023

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Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.

  • Jordan P; Costa A; Specker E; Popp O; Volkamer A; Piske R; Obrusnik T; Kleissle S; Stuke K; Rex A; Neuenschwander M; von Kries JP; Nazare M; Wolf SA

PloS one 2023

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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.

  • Ahmed SM; Ragunathan P; Shin J; Peter S; Kleissle S; Neuenschwander M; Schäfer R; Kries JPV; Grüber G; Dröge P

FEBS letters 2023

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Glycolytic flux control by drugging phosphoglycolate phosphatase.

  • Jeanclos E; Schlötzer J; Hadamek K; Yuan-Chen N; Alwahsh M; Hollmann R; Fratz S; Yesilyurt-Gerhards D; Frankenbach T; Engelmann D; Keller A; Gohla A

Nature communications 2022

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TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.

  • Tufan AB; Lazarow K; Kolesnichenko M; Sporbert A; von Kries JP; Scheidereit C

The EMBO journal 2022

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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.

  • Lo WT; Belabed H; Kücükdisli M; Metag J; Roske Y; Prokofeva P; Ohashi Y; Horatscheck A; Cirillo D; Krauss M; Schmied C; Neuenschwander M; Haucke V

Nature chemical biology 2022

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Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.

  • Specker E; Matthes S; Wesolowski R; Schütz A; Grohmann M; Alenina N; Pleimes D; Mallow K; Neuenschwander M; Gogolin A; Weise M; Pfeifer J; Ziebart N; Bader M

Journal of medicinal chemistry 2022

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Disruptors of AKAP-Dependent Protein-Protein Interactions.

  • Walker-Gray R; Pallien T; Miller DC; Oder A; Neuenschwander M; von Kries JP; Diecke S; Klussmann E

Methods in molecular biology (Clifton, N.J.) 2022

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Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

  • Sandrine Baltzer; Timur Bulatov; Christopher Schmied; Andreas Krämer; Benedict-Tilman Berger; Andreas Oder; Ryan Walker-Gray; Christin Kuschke; Kerstin Zühlke; Jenny Eichhorst; Martin Lehmann; Stefan Knapp; John Weston; Jens Von Kries; Roderich D. Süssmuth; Enno Klussmann

International Journal of Molecular Sciences 2022

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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy.

  • Marcinkowski P; Hoyer I; Specker E; Furkert J; Rutz C; Neuenschwander M; Sobottka S; Sun H; Nazare M; Berchner-Pfannschmidt U; von Kries JP; Krause G

Thyroid : official journal of the American Thyroid Association 2018

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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.

  • Klein W; Rutz C; Eckhard J; Provinciael B; Specker E; Neuenschwander M; Kleinau G; Scheerer P; von Kries JP; Nazaré M; Vermeire K; Schülein R

PloS one 2018

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Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.

  • Otten C; Knox J; Boulday G; Eymery M; Haniszewski M; Neuenschwander M; Radetzki S; Vogt I; Hähn K; De Luca C; Cardoso C; Hamad S; Igual Gil C; Roy P; Abdelilah-Seyfried S

EMBO molecular medicine 2018

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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

  • Liss M; Radke MH; Eckhard J; Neuenschwander M; Dauksaite V; von Kries JP; Gotthardt M

PloS one 2018

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Loss-of-function uORF mutations in human malignancies.

  • Schulz J; Mah N; Neuenschwander M; Kischka T; Ratei R; Schlag PM; Castaños-Vélez E; Fichtner I; Tunn PU; Denkert C; Klaas O; Berdel WE; von Kries JP; Wethmar K

Scientific reports 2018

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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

  • Schrade K; Tröger J; Eldahshan A; Zühlke K; Abdul Azeez KR; Elkins JM; Neuenschwander M; Oder A; Elkewedi M; Jaksch S; Andrae K; Li J; Fernandes J; Klussmann E

PloS one 2018

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Small Molecules Targeting Human N-Acetylmannosamine Kinase.

  • Hinderlich S; Neuenschwander M; Wratil PR; Oder A; Lisurek M; Nguyen LD; von Kries JP; Hackenberger CPR

Chembiochem : a European journal of chemical biology 2017

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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

  • Anumala UR; Waaler J; Nkizinkiko Y; Ignatev A; Lazarow K; Lindemann P; Olsen PA; Murthy S; Obaji E; Majouga AG; Leonov S; von Kries JP; Lehtiö L; Nazaré M

Journal of medicinal chemistry 2017

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A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.

  • Fetzer C; Korotkov VS; Thänert R; Lee KM; Neuenschwander M; von Kries JP; Medina E; Sieber SA

Angewandte Chemie (International ed. in English) 2017

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Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of <i>aqp-8</i> in <i>C. elegans</i>.

  • Igual Gil C; Jarius M; von Kries JP; Rohlfing AK

Frontiers in physiology 2017

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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.

  • Juneja M; Kobelt D; Walther W; Voss C; Smith J; Specker E; Neuenschwander M; Gohlke BO; Dahlmann M; Radetzki S; Preissner R; von Kries JP; Schlag PM; Stein U

PLoS biology 2017

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Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

  • Carter DM; Specker E; Przygodda J; Neuenschwander M; von Kries JP; Heinemann U; Nazaré M; Gohlke U

SLAS discovery : advancing life sciences R & D 2017

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