[Translate to Deutsch:] Portrait Vince

Dr.

Jan Vincent Arafiles

Post-Doktorand:in Hackenberger Gruppe

 +49 30 94793 287

+49 30 94793 188

 arafiles@fmp-berlin.de

@VinceArafiles

@VinceArafiles

0000-0002-7733-7563

Vince stammt ursprünglich aus den sonnigen Philippinen und promovierte an der Kyoto University, Japan, bei Prof. Shiroh Futaki, finanziert durch das MEXT-Stipendium. Er arbeitete an einer peptidbasierten Strategie, die Makropinozytose-Induktion und Endosomenfreisetzung für die intrazelluläre Abgabe von Biomakromolekülen kombiniert. Vince wollte mehr Chemie lernen und zog als Postdoc in die Hackenberger-Gruppe ans andere Ende der Welt. Er führt Mikroskopietechniken durch, um die zellulären Eintrittsmechanismen zu untersuchen und die Wirksamkeit von zellpenetrierenden Peptiden (CPP) und CPP-Additiven zu optimieren. Abseits des Labors mag er es asiatische Gerichte zu kochen, Drinks und Pub-Quiz.

  • PostDoc Repräsentation

Chemische Biologie


Hackenberger Gruppe


FMP

Publikationen

Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold

  • Yuki Nagano; Jan Vincent V. Arafiles; Keiko Kuwata; Yoshimasa Kawaguchi; Miki Imanishi; Hisaaki Hirose; Shiroh Futaki

Molecular Pharmaceutics 2022

online lesen

Artificial Nanocage Formed via Self-Assembly of β-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors

  • Kentarou Sakamoto; Hiroto Furukawa; Jan Vincent V. Arafiles; Miki Imanishi; Kazunori Matsuura; Shiroh Futaki

Bioconjugate Chemistry 2022

online lesen

Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles

  • Yuna Nakagawa; Jan Vincent V. Arafiles; Yoshimasa Kawaguchi; Ikuhiko Nakase; Hisaaki Hirose; Shiroh Futaki

Bioconjugate Chemistry 2022

online lesen

Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell‐Penetrating Peptides for Live‐Cell Delivery of Synthetic Proteins

  • Abhishek Saha; Shaswati Mandal; Jan Vincent V. Arafiles; Jacobo Gómez‐González; Christian P. R. Hackenberger; Ashraf Brik

Angewandte Chemie International Edition 2022

online lesen

Struktur‐Wirkungsbeziehung von an zyklische Zell‐penetrierende Peptide gebundenen DABCYL‐Derivaten für den Transport von synthetischen Proteinen in lebende Zellen

  • Abhishek Saha; Shaswati Mandal; Jan Vincent V. Arafiles; Jacobo Gómez‐González; Christian P. R. Hackenberger; Ashraf Brik

Angewandte Chemie 2022

online lesen

Modular solid-phase synthesis of electrophilic cysteine-selective ethynyl-phosphonamidate peptides

  • Sarah Hansen; Jan Vincent V. Arafiles; Philipp Ochtrop; Christian P. R. Hackenberger

Chemical Communications 2022

online lesen

Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells

  • Masashi Kuriyama; Hisaaki Hirose; Toshihiro Masuda; Masachika Shudou; Jan Vincent V. Arafiles; Miki Imanishi; Masashi Maekawa; Yuji Hara; Shiroh Futaki

Scientific Reports 2022

online lesen
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Chemical passports to cross biological borders

  • Arafiles, J.V.V.; Futaki, S.

Nature Chemistry 2021

online lesen

Cover Picture: Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides (Angew. Chem. Int. Ed. 36/2021)

  • Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V. Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

Angewandte Chemie International Edition 2021

online lesen

Use of homoarginine to obtain attenuated cationic membrane lytic peptides.

  • Sakamoto K; Akishiba M; Iwata T; Arafiles JVV; Imanishi M; Futaki S

Bioorganic & medicinal chemistry letters 2021

online lesen

Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

  • Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V. Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

Angewandte Chemie 2021

online lesen

Titelbild: Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides (Angew. Chem. 36/2021)

  • Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V. Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

Angewandte Chemie 2021

online lesen

Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation

  • Arafiles, J.V.V.; Hirose, H.; Hirai, Y.; Kuriyama, M.; Sakyiamah, M.M.; Nomura, W.; Sonomura, K.; Imanishi, M.; Otaka, A.; Tamamura, H.; Futaki, S.

Angewandte Chemie - International Edition 2021

online lesen

Piezo1 activation using Yoda1 inhibits macropinocytosis and proliferation of cancer cells

  • Kuriyama M; Hirose H; Masuda T; Shudou M; Arafiles JVV; Imanishi M; Maekawa M; Hara Y; Futaki S
online lesen

Discovery of a Macropinocytosis‐Inducing Peptide Potentiated by Medium‐Mediated Intramolecular Disulfide Formation

  • Jan Vincent V. Arafiles; Hisaaki Hirose; Yusuke Hirai; Masashi Kuriyama; Maxwell Mamfe Sakyiamah; Wataru Nomura; Kazuhiro Sonomura; Miki Imanishi; Akira Otaka; Hirokazu Tamamura; Shiroh Futaki

Angewandte Chemie 2021

online lesen

A facile combinatorial approach to construct a ratiometric fluorescent sensor: application for the real-time sensing of cellular pH changes

  • Eiji Nakata; Hisaaki Hirose; Khongorzul Gerelbaatar; Jan Vincent V. Arafiles; Zhengxiao Zhang; Shiroh Futaki; Takashi Morii

Chemical Science 2021

online lesen

Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

  • Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V. Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

Angewandte Chemie International Edition 2021

online lesen
von 10