Dr.

Edgar Specker

Leitung Compound Management

Edgar Specker studierte Chemie an der Universität Münster. Nach seiner Diplomarbeit bei der Bayer AG erhielt er seinen Doktortitel im Jahr 2004 in der Arbeitsgruppe von Prof. Klebe an der Universität in Marburg. Seine PostDoc Zeit verbrachte er in der Arbeitsgruppe von Prof. Bradley an den Universitäten Southampton und Edinburgh. Ende 2005 arbeitete er als Medizinalchemiker in der Biotech Firma Zedira GmbH, wo er Inhibitoren von Transglutaminasen zur Behandlung von Zöliakie synthetisierte. Im Jahr 2007 wechselte er zur Pharmafirma Jerini AG und kollaborierte dort in einem Drug Discovery Projekt mit der Firma Alcon. Für das Compound Management am FMP ist er seit 2010 zunächst als Teil der Screening Unit und anschließend als Mitarbeiter in der Arbeitsgruppe Medizinische Chemie tätig. Seit 2020 ist er Leiter der eigenständigen Technologieplattform Compound Management am FMP. Er hat über die letzten drei Jahre das Compound Management von EU-OPENSCREEN ERIC mit aufgebaut. Zudem ist er Mitgründer der Start-up Firma Trypto Therapeutics GmbH.

Weitere Position

Co-founder Trypto Therapeutics GmbH

Forschungsbereich

Chemische Biologie

Forschungsgruppen / Technologieplattformen

Compound Management

Einrichtungen

FMP
Trypto Therapeutics GmbH

Publikationen

2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2007 2006 2005 2004

Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression

Ekaterina Legchenko; Philippe Chouvarine; Fatimunnisa Qadri; Edgar Specker; Marc Nazaré; Radoslaw Wesolowski; Susann Matthes; Michael Bader; Georg Hansmannn

JACC: Basic to Translational Science 2024

online lesen

TPT‐004, a Next‐Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats

Radoslaw Wesolowski; Dirk Pleimes; Edgar Specker; Michael Bader

Journal of the American Heart Association 2024

online lesen

Design, Quality and Validation of the EU-OPENSCREEN Fragment Library Poised to a High-Throughput Screening Collection

Xavier Jalencas; Hannes Berg; Ludvik Olai Espeland; Sridhar Sreeramulu; Franziska Kinnen; Christian Richter; Charis Georgiou; Vladyslav Yadrykhinsky; Edgar Specker; Kristaps Jaudzems; Tanja Miletić; Robert Harmel; Phil Gribbon; Harald Schwalbe; Ruth Brenk; Aigars Jirgensons; Andrea Zaliani; Jordi Mestres

RSC Medicinal Chemistry 2024

online lesen

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

Saif Mohd; Andreas Oder; Edgar Specker; Martin Neuenschwander; Jens Peter Von Kries; Oliver Daumke

PLOS ONE 2024

online lesen

Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors

Edgar Specker; Radoslaw Wesolowski; Anja Schütz; Susann Matthes; Keven Mallow; Malgorzata Wasinska-Kalwa; Lars Winkler; Andreas Oder; Natalia Alenina; Dirk Pleimes; Jens Peter von Kries; Udo Heinemann; Michael Bader; Marc Nazaré

Journal of Medicinal Chemistry 2023

online lesen

Small Molecules Targeting Human UDP‐GlcNAc 2‐Epimerase

Jacob L. Gorenflos López; Gillian L. Dornan; Nico Boback; Martin Neuenschwander; Andreas Oder; Kristin Kemnitz‐Hassanin; Peter Schmieder; Edgar Specker; Hatice Ceyda Asikoglu; Christian Oberdanner; Carola Seyffarth; Jens Peter von Kries; Daniel Lauster; Stephan Hinderlich; Christian P.R. Hackenberger

ChemBioChem 2023

online lesen

Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

Philipp Jordan; Amanda Costa; Edgar Specker; Oliver Popp; Andrea Volkamer; Regina Piske; Tessa Obrusnik; Sabrina Kleissle; Kevin Stuke; André Rex; Martin Neuenschwander; Jens Peter von Kries; Marc Nazare; Phillip Mertins; Helmut Kettenmann; Susanne A. Wolf

PLOS ONE 2023

online lesen

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

Shixian Yan; Paul Curtis Schöpe; Joe Lewis; Kerstin Putzker; Ulrike Uhrig; Edgar Specker; Jens Peter von Kries; Peter Lindemann; Anahid Omran; Hector E. Sanchez-Ibarra; Anke Unger; Mia-Lisa Zischinsky; Bert Klebl; Wolfgang Walther; Marc Nazaré; Dennis Kobelt; Ulrike Stein

Biomedicine & Pharmacotherapy 2023

online lesen

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition

Murat Kücükdisli; Hassen Bel-Abed; Davide Cirillo; Wen-Ting Lo; Nina-Louisa Efrém; André Horatscheck; Liudmila Perepelittchenko; Polina Prokofeva; Theresa A. L. Ehret; Silke Radetzki; Martin Neuenschwander; Edgar Specker; Guillaume Médard; Susanne Müller; Stephanie Wilhelm; Bernhard Kuster; Jens Peter von Kries; Volker Haucke; Marc Nazare

Journal of Medicinal Chemistry 2023

online lesen

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors

Edgar Specker; Susann Matthes; Radoslaw Wesolowski; Anja Schütz; Maik Grohmann; Natalia Alenina; Dirk Pleimes; Keven Mallow; Martin Neuenschwander; Angelina Gogolin; Marie Weise; Jochen Pfeifer; Nandor Ziebart; Udo Heinemann; Jens Peter von Kries; Marc Nazaré; Michael Bader

Journal of Medicinal Chemistry 2022

online lesen

Probing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands

María Isabel Fernández-Bachiller; Songhwan Hwang; María Elena Schembri; Peter Lindemann; Mónica Guberman; Svenja Herziger; Edgar Specker; Hans Matter; David W. Will; Jörg Czech; Michael Wagner; Armin Bauer; Herman Schreuder; Kurt Ritter; Matthias Urmann; Volkmar Wehner; Han Sun; Marc Nazaré

Journal of Medicinal Chemistry 2022

online lesen

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis

Hanna Bonnekoh; Carolina Vera; Angela Abad‐Perez; Silke Radetzki; Martin Neuenschwander; Edgar Specker; Niklas Amadeus Mahnke; Stefan Frischbutter; Eicke Latz; Marc Nazaré; Jens v. Kries; Marcus Maurer; Jörg Scheffel; Karoline Krause

Clinical and Translational Allergy 2021

online lesen

Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer

David M. Carter; Edgar Specker; Piotr H. Małecki; Jessica Przygodda; Krystyna Dudaniec; Manfred S. Weiss; Udo Heinemann; Marc Nazare; Ulrich Gohlke

Journal of Medicinal Chemistry 2021

online lesen

NMR quality control of fragment libraries for screening

Sreeramulu, Sridhar; Richter, Christian; Kuehn, Till; Azzaoui, Kamal; Blommers, Marcel Jules José; Conte, Rebecca Del; Fragai, Marco; Trieloff, Nils; Schmieder, Peter; Nazaré, Marc; Specker, Edgar; Ivanov, Vladimir; Oschkinat, Hartmut; Banci, Lucia; Schwalbe, Harald

Journal of biomolecular NMR 2020

online lesen

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Ioanna Plastira; Lisha Joshi; Eva Bernhart; Jens Schoene; Edgar Specker; Marc Nazare; Wolfgang Sattler

Frontiers in Cellular Neuroscience 2019

online lesen

EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

Philip Brennecke; Dace Rasina; Oscar Aubi; Katja Herzog; Johannes Landskron; Bastien Cautain; Francisca Vicente; Jordi Quintana; Jordi Mestres; Bahne Stechmann; Bernhard Ellinger; Jose Brea; Jacek L. Kolanowski; Radosław Pilarski; Mar Orzaez; Antonio Pineda-Lucena; Luca Laraia; Faranak Nami; Piotr Zielenkiewicz; Kamil Paruch; Espen Holst Hansen; Jens P. von Kries; Martin Neuenschwander; Edgar Specker; Petr Bartunek; Sarka Simova; Zbigniew Leśnikowski; Stefan Krauss; Lari Lehtiö; Ursula Bilitewski; Mark Brönstrup; Kjetil Taskén; Aigars Jirgensons; Heiko Lickert; Mads H. Clausen; Jeanette H. Andersen; Maria J. Vicent; Olga Genilloud; Aurora Martinez; Marc Nazaré; Wolfgang Fecke; Philip Gribbon

SLAS Discovery 2019

online lesen

A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy

Patrick Marcinkowski; Inna Hoyer; Edgar Specker; Jens Furkert; Claudia Rutz; Martin Neuenschwander; Sebastian Sobottka; Han Sun; Marc Nazare; Utta Berchner-Pfannschmidt; Jens Peter von Kries; Anja Eckstein; Ralf Schülein; Gerd Krause

Thyroid 2019

online lesen

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Wolfgang Klein; Claudia Rutz; Jamina Eckhard; Becky Provinciael; Edgar Specker; Martin Neuenschwander; Gunnar Kleinau; Patrick Scheerer; Jens-Peter von Kries; Marc Nazaré; Kurt Vermeire; Ralf Schülein

PLOS ONE 2018

online lesen

CellFy: A Cell-Based Fragment Screen against C-Type Lectins

Jessica Schulze; Hannes Baukmann; Robert Wawrzinek; Felix F. Fuchsberger; Edgar Specker; Jonas Aretz; Marc Nazare; Christoph Rademacher

ACS Chemical Biology 2018

online lesen

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells

David M. Carter; Edgar Specker; Jessica Przygodda; Martin Neuenschwander; Jens Peter von Kries; Udo Heinemann; Marc Nazaré; Ulrich Gohlke

SLAS Discovery 2017

online lesen

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

Manisha Juneja; Dennis Kobelt; Wolfgang Walther; Cynthia Voss; Janice Smith; Edgar Specker; Martin Neuenschwander; Björn-Oliver Gohlke; Mathias Dahlmann; Silke Radetzki; Robert Preissner; Jens Peter von Kries; Peter Michael Schlag; Ulrike Stein

PLOS Biology 2017

online lesen

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

Christiane Wetzel; Simone Pifferi; Cristina Picci; Caglar Gök; Diana Hoffmann; Bali KK; André Lampe; Liudmila Lapatsina; Raluca Fleischer; Ewan Smith; Valérie Bégay; Mirko Moroni; Luc Estebanez; Johannes Kühnemund; Jan Walcher; Edgar Specker; Martin Neuenschwander; Jens Peter von Kries; Volker Haucke; Rohini Kuner; James F A Poulet; Jan Schmoranzer; Kate Poole; Lewin GR

Nature Neuroscience 2017

online lesen

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

Jing Du; Martin Neuenschwander; Yong Yu; J. Henry M. Däbritz; Nina-Rosa Neuendorff; Kolja Schleich; Aitomi Bittner; Maja Milanovic; Gregor Beuster; Silke Radetzki; Edgar Specker; Maurice Reimann; Frank Rosenbauer; Stephan Mathas; Philipp Lohneis; Michael Hummel; Bernd Dörken; Jens Peter von Kries; Soyoung Lee; Clemens A. Schmitt

Blood 2017

online lesen

A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

Liang Fang; Qionghua Zhu; Martin Neuenschwander; Edgar Specker; Annika Wulf-Goldenberg; William I. Weis; Jens P. von Kries; Walter Birchmeier

Cancer Research 2016

online lesen

Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures

Michel-Andreas Geiger; Marcella Orwick-Rydmark; Katharina Märker; W. Trent Franks; Dmitry Akhmetzyanov; Daniel Stöppler; Maximilian Zinke; Edgar Specker; Marc Nazaré; Anne Diehl; Barth-Jan van Rossum; Fabien Aussenac; Thomas Prisner; Ümit Akbey; Hartmut Oschkinat

Physical Chemistry Chemical Physics 2016

online lesen

Design of a General‐Purpose European Compound Screening Library for EU‐OPENSCREEN

Dragos Horvath; Michael Lisurek; Bernd Rupp; Ronald Kühne; Edgar Specker; Jens von Kries; Didier Rognan; C. David Andersson; Fredrik Almqvist; Mikael Elofsson; Per‐Anders Enqvist; Anna‐Lena Gustavsson; Nikita Remez; Jordi Mestres; Gilles Marcou; Alexander Varnek; Marcel Hibert; Jordi Quintana; Ronald Frank

ChemMedChem 2014

online lesen

Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform

Felix Wilde; Edgar Specker; Martin Neuenschwander; Marc Nazaré; Anja Bodtke; Andreas Link

Molecular Diversity 2014

online lesen

Determination of glucan phosphorylation using heteronuclear 1H,13C double and 1H,13C,31P triple‐resonance NMR spectra

Peter Schmieder; Felix Nitschke; Martin Steup; Keven Mallow; Edgar Specker

Magnetic Resonance in Chemistry 2013

online lesen

Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines

Christoph Kamper; Katharina Korpis; Edgar Specker; Lennart Anger; Martin Neuenschwander; Patrick J. Bednarski; Andreas Link

Molecular Diversity 2012

online lesen

Neurotoxin II Bound to Acetylcholine Receptors in Native Membranes Studied by Dynamic Nuclear Polarization NMR

Arne H. Linden; Sascha Lange; W. Trent Franks; Ümit Akbey; Edgar Specker; Barth-Jan van Rossum; Hartmut Oschkinat

Journal of the American Chemical Society 2011

online lesen

Aspartic Acid Proteases as Therapeutic Targets. Edited by Arun K. Ghosh.

Edgar Specker

ChemMedChem 2011

online lesen

A highly sensitive fluorometric assay for determination of human coagulation factor XIII in plasma

Kai Oertel; Andreas Hunfeld; Edgar Specker; Christine Reiff; Rainer Seitz; Ralf Pasternack; Johannes Dodt

Analytical Biochemistry 2007

online lesen

Unexpected Novel Binding Mode of Pyrrolidine‐Based Aspartyl Protease Inhibitors: Design, Synthesis and Crystal Structure in Complex with HIV Protease

Edgar Specker; Jark Böttcher; Sascha Brass; Andreas Heine; Hauke Lilie; Andreas Schoop; Gerhard Müller; Nils Griebenow; Gerhard Klebe

ChemMedChem 2006

online lesen

Zwei neue privilegierte Bausteine und ein unerwarteter Bindungsmodus für HIV‐Protease‐Inhibitoren †

Edgar Specker; Jark Böttcher; Hauke Lilie; Andreas Heine; Andreas Schoop; Gerhard Müller; Nils Griebenow; Gerhard Klebe

Angewandte Chemie 2005

online lesen

An Old Target Revisited: Two New Privileged Skeletons and an Unexpected Binding Mode For HIV‐Protease Inhibitors †

Edgar Specker; Jark Böttcher; Hauke Lilie; Andreas Heine; Andreas Schoop; Gerhard Müller; Nils Griebenow; Gerhard Klebe

Angewandte Chemie 2005

online lesen

Hydroxyethylene sulfones as a new scaffold to address aspartic proteases

Specker, Edgar; Böttcher, Jark; Heine, Andreas; Sotriffer, Christoph A.; Lilie, Hauke; Schoop, Andreas; Müller, Gerhard; Griebenow, Nils; Klebe, Gerhard

Journal of medicinal chemistry 2005

online lesen

Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA–peptide conjugates

Laurent Bialy; Juan José Díaz-Mochón; Edgar Specker; Lise Keinicke; Mark Bradley

Tetrahedron 2005

online lesen

De-novo-Design und Synthese neuer Leitstrukturen als Übergangszustandsmimetika zur selektiven Inhibition der HIV-1-Protease und Cathepsin D

Edgar Specker